| Gene Symbol | PLD4 |
| Function | encodes a member of the phospholipase D family that possesses both phospholipase D enzymatic activity and 5'→3' exonuclease capability. |
| Subcellular Localization | - **Microglia**: The resident immune cells of the central nervous system |
| Ensembl ID | ENSG00000138184 |
| GeneCards | PLD4 |
| Human Protein Atlas | PLD4 |
| Mitochondrial DNA clearance | PLD4 degrades mitochondrial DNA (mtDNA) released into the cytosol, preventing excessive TLR9 activation[@moriya2019] |
| Prevention of autoinflammation | By clearing nucleic acid debris, PLD4 maintains immune tolerance and prevents inappropriate activation of innate immune sensors |
| Generation of TLR7 ligands | Paradoxically, PLD4 can also cleave viral RNA to generate ligands for TLR7, enabling antiviral immunity[@gondard2017] |
| Microglia | The resident immune cells of the central nervous system |
| Astrocytes | To a lesser extent |
| Oligodendrocytes | In white matter regions |
| TLR9 | Negatively regulates TLR9-mediated signaling |
| TLR7 | Can generate ligands for TLR7 activation |
| ATG proteins | Involved in autophagy and lysosomal function |
| Associated Diseases | neurodegeneration |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |