| Gene Symbol | PLXNA2 |
| Chromosome | 1q23.3 |
| Protein Type | Gene |
| Function | encodes a member of the plexin family of transmembrane receptors for semaphorins, playing critical roles in neural development, circuit formation, and synaptic plasticity. |
| Molecular Weight | 220 kDa |
| Amino Acids | 034 aa |
| Exons | 33 |
| GeneCards | PLXNA2 |
| Human Protein Atlas | PLXNA2 |
| Cerebellum | Purkinje cells and granule cells |
| Olfactory bulb | mitral and tufted cells |
| Thalamus | relay neurons |
| Substantia nigra | dopaminergic neurons |
| Axonal repulsion | SEMA3A binding to PLXNA2 triggers growth cone collapse through RhoA/ROCK-dependent cytoskeletal remodeling[@plexin2021] |
| Synaptic scaling | PLXNA2 modulates AMPA receptor trafficking via Rap GAP activity[@plexin2022] |
| Associated Diseases | neurodegeneration |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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