Contents

PPM1A Gene

🧬 Gene Info

Gene Symbol	PPM1A
Aliases	PP2Cα
Chromosome	14q23.1
Protein Type	Phosphatase
Function	GSK3β sites: Ser199, Ser202, Thr231, Ser396, Ser404
Molecular Weight	39.2 kDa
Amino Acids	382 aa
Exons	8
Pathways	TGF-β signaling, TGF-β Signaling, TGF-β, MAPK Pathway
Ensembl ID	ENSG00000163209
GeneCards	PPM1A
Human Protein Atlas	PPM1A
Catalytic domain	Contains the binuclear metal ion center (Mg2+/Mn2+)
N-terminal extension	Regulates substrate specificity
Monomeric enzyme	Unlike PP2A, functions without regulatory subunits
Associated Diseases	neurodegeneration
Databases	GeneCards UniProt NCBI Gene HPA STRING

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