| Gene Symbol | PRKAR1A |
| Full Name | Protein Kinase A Regulatory Subunit 1 Alpha |
| Function | encodes the type 1A (RIα) regulatory subunit of cAMP-dependent protein kinase (PKA), also known as protein kinase A[@walsh1966] |
| Ensembl ID | ENSG00000163644 |
| GeneCards | PRKAR1A |
| Human Protein Atlas | PRKAR1A |
| RIα (PRKAR1A product) | Ubiquitously expressed, first discovered |
| RIβ | Enriched in brain |
| RIIα | Widely expressed |
| RIIβ | Enriched in brain and endocrine tissues |
| N-terminal dimerization domain (D/D) | Mediates R-subunit homodimerization |
| Linker region | Contains substrate docking and inhibition sequences |
| C-terminal region | Contributes to structural stability |
| Catalytic core | Kinase domain with activation loop phosphorylation site (Thr197 in Cα) |
| Myristylation site | N-terminal Gly that anchors C subunits to membranes |
| Associated Diseases | neurodegeneration |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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