| Gene Symbol | PRKCZ |
| Protein Type | Kinase |
| Function | PRKCZ is an atypical protein kinase C isoform that differs from conventional PKCs in its regulation and substrate specificity. |
| Primary Expression | the nervous system: |
| Subcellular Localization | **Cytoplasm**: Basal state localization |
| Pathways | NF-κB, mTOR, mtor |
| Ensembl ID | ENSG00000167614 |
| GeneCards | PRKCZ |
| Human Protein Atlas | PRKCZ |
| Regulatory Domain | PB1 (Phox and Bem1) domain for protein-protein interactions |
| Kinase Domain | Catalytic domain with atypical zinc finger motif |
| Unique N-terminal Region | Mediates localization and protein interactions |
| Insulin Signaling | Central node in insulin receptor signaling and GLUT4 translocation [@farese2005] |
| Cell Polarity | Regulation of cell junction assembly and apical-basal polarity [@martin2012] |
| Synaptic Plasticity | Control of AMPA receptor trafficking and long-term potentiation [@zhang2011] |
| Associated Diseases | neurodegeneration |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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