| Gene Symbol | PRKG1 |
| Full Name | Protein Kinase cGMP-Dependent 1 |
| Chromosome | 10q21.3 |
| Protein Type | Serine/Threonine Kinase |
| Function | is a key effector of the nitric oxide (NO)-cGMP signaling pathway and plays important roles in neuronal function, synaptic plasticity, and cardiovascular regulation. |
| NCBI Gene ID | 5590 |
| GeneCards | PRKG1 |
| Human Protein Atlas | PRKG1 |
| PKG1α | Higher affinity for cGMP, predominant in cerebellum |
| PKG1β | Lower cGMP affinity, more widely expressed [@pkg] |
| Synaptic plasticity | PKG is required for long-term potentiation (LTP) and long-term depression (LTD) [@pkga] |
| Gene expression | Phosphorylates transcription factors including CREB |
| Ion channel function | Modulates NMDA receptor activity and calcium channels |
| Dendritic spine morphology | Regulates spine formation and maintenance [@pkg2003] |
| Axon guidance | Controls growth cone dynamics |
| Associated Diseases | neurodegeneration |
| Databases | GeneCardsUniProtHPASTRING |
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