gene 1,835 words KG: PROSAP1
Contents

PROSAP1 - Proline-Rich Synaptic-Associated Protein 1 (SHANK2)

🧬 Gene Info
Gene SymbolPROSAP1
Full NameProline-Rich Synaptic-Associated Protein 1 (SHANK2)
Chromosome11q13.2
Protein TypeScaffold Protein
Functionis a critical postsynaptic scaffold protein that orchestrates the organization of the postsynaptic density (PSD) in excitatory synapses.
Primary Expressionheart, skeletal muscle, and testis
Molecular Weight225 kDa
Amino Acids070 aa
Exons24
UniProt IDQ9UHB6
NCBI Gene ID22989
Ensembl IDENSG00000046192
OMIM606344
GeneCardsPROSAP1
Human Protein AtlasPROSAP1
Associated Diseasesneurodegeneration
DatabasesGeneCardsHPASTRING

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Related Hypotheses (11)

APOE-Dependent Autophagy Restoration
Score: 0.89
Hippocampal CA3-CA1 circuit rescue via neurogenesis and syna
Score: 0.82
Senescence-Associated Myelin Lipid Remodeling
Score: 0.73
Sleep Spindle-Synaptic Plasticity Enhancement
Score: 0.72
TREM2 Conformational Stabilizers for Synaptic Discrimination
Score: 0.69
Glycine-Rich Domain Competitive Inhibition
Score: 0.64
Heat Shock Protein 70 Disaggregase Amplification
Score: 0.62
Synaptic Phosphatidylserine Masking via Annexin A1 Mimetics
Score: 0.62
Serine/Arginine-Rich Protein Kinase Modulation
Score: 0.62
Synaptic Vesicle Tau Capture Inhibition
Score: 0.58
Trans-Synaptic Adhesion Molecule Modulation
Score: 0.54

Related Analyses (13)

Tau propagation mechanisms and therapeutic interception poin
neurodegeneration · archived
Senolytic therapy for age-related neurodegeneration
neurodegeneration · archived
Sleep disruption as cause and consequence of neurodegenerati
neurodegeneration · archived
Synaptic pruning by microglia in early AD
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

See Also (1)

Neurodegeneration
disease · KG edge: implicated_in

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