| Gene Symbol | RAB15 |
| Function | RAB15 is a brain-enriched Rab GTPase that plays crucial roles in synaptic vesicle endocytosis and recycling. |
| Ensembl ID | ENSG00000139836 |
| GeneCards | RAB15 |
| Human Protein Atlas | RAB15 |
| Synaptic Vesicle Endocytosis | Rab15 specifically regulates clathrin-mediated endocytosis at presynaptic terminals [@clathrinmediated2017] |
| Vesicle Recycling | Coordinates the recycling of synaptic vesicles after neurotransmitter release |
| Neurotransmitter Receptor Trafficking | Regulates the endocytosis and recycling of AMPA and NMDA receptors at postsynaptic sites [@postsynaptic2019] |
| Early Endosome Function | Controls the maturation and sorting of early endosomes in neurons |
| Synaptic Vesicle Replenishment | Essential for rapid recycling of synaptic vesicles during sustained neuronal activity |
| Postsynaptic Receptor Turnover | Regulates the replacement of synaptic receptors during synaptic plasticity |
| Axon Initial Segment Function | Important for maintaining protein composition at the axon initial segment |
| Dendritic Spine Endocytosis | Facilitates clathrin-mediated endocytosis in dendritic spines [@dendritic2020] |
| Striatum | Medium spiny neurons |
| Cerebellum | Purkinje cells |
| Associated Diseases | neurodegeneration |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |