| Gene Symbol | RAB6A |
| Function | RAB6A is a Golgi-resident small GTPase that regulates retrograde transport from the Golgi to the endoplasmic reticulum (ER). |
| Primary Expression | motor neurons, which are selectively affected in ALS |
| Ensembl ID | ENSG00000168244 |
| GeneCards | RAB6A |
| Human Protein Atlas | RAB6A |
| Retrograde Transport | Rab6A coordinates the retrieval of cargo from the Golgi back to the ER, a fundamental process for maintaining ER-Golgi homeostasis [@golgier2017] |
| Golgi Organization | The protein maintains Golgi stack morphology and function through regulation of COPI vesicle trafficking |
| Vesicle Tethering | Rab6A interacts with effector proteins including p115, GM130, and GRASP65 to tether vesicles to their correct destinations |
| Cytoskeletal Regulation | Rab6A modulates microtubule-based transport and interacts with dynein/dynactin motor complexes [@raba2019] |
| Synaptic Vesicle Recycling | Rab6A regulates the retrieval of synaptic vesicle components after neurotransmitter release |
| Protein Quality Control | The Golgi-ER retrieval pathway is essential for disposing of misfolded proteins and maintaining proteostasis |
| Axonal Transport | Rab6A-mediated trafficking is crucial for transporting proteins along axons and dendrites |
| Dendritic Spine Morphogenesis | Rab6A function influences the formation and maintenance of dendritic spines [@rab2020a] |
| Brain | Particularly in neurons of the basal ganglia, hippocampus, cerebral cortex, and motor neurons of the spinal cord |
| Associated Diseases | neurodegeneration |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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