| Gene Symbol | RAB6B |
| Function | RAB6B is a brain-specific isoform of RAB6A, with over 90% sequence identity, but with distinct neuronal expression patterns and functions. |
| Ensembl ID | ENSG00000154917 |
| GeneCards | RAB6B |
| Human Protein Atlas | RAB6B |
| Dendritic Protein Trafficking | Rab6B specifically regulates the trafficking of proteins in dendrites, including neurotransmitter receptors and synaptic proteins [@regulation2017] |
| Retrograde Transport | Coordinates retrieval of cargo from the Golgi to the ER in neuronal processes |
| Synaptic Protein Delivery | Essential for delivering newly synthesized synaptic proteins to dendritic spines |
| Dendritic Golgi Outposts | Maintains Golgi outposts in dendrites that support local protein synthesis and trafficking [@local2019] |
| Synaptic Plasticity | Regulates the delivery and turnover of synaptic proteins during long-term potentiation (LTP) and long-term depression (LTD) |
| Dendritic Spine Maintenance | Essential for maintaining dendritic spine morphology and function |
| Local Protein Synthesis | Supports dendritic protein synthesis through trafficking of translation components |
| Neurotransmitter Receptor Trafficking | Regulates the surface expression of AMPA and NMDA receptors [@ampa2020] |
| Cerebellum | Particularly enriched in Purkinje cells |
| Hippocampus | High expression in CA1 pyramidal neurons and dentate gyrus granule cells |
| Associated Diseases | neurodegeneration |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |