| Gene Symbol | RASP |
| Function | As with other Ras family members, this cycling regulates its ability to interact with downstream effectors. |
| Primary Expression | Purkinje cells and granule cells - Substantia Nigra: Present in dopaminergic neurons - Basal Ganglia: Expression in striatal medium spiny neur |
| Amino Acids | 276 aa |
| Ensembl ID | ENSG00000113595 |
| GeneCards | RASP |
| Human Protein Atlas | RASP |
| Brain-enriched expression | Highest expression in the cerebral cortex, hippocampus, and cerebellum |
| Activity-dependent regulation | Expression and activation are modulated by neuronal activity |
| Synaptic localization | Enriched at synaptic terminals, particularly in postsynaptic densities |
| Long-term potentiation (LTP) | RASP1 signaling contributes to LTP induction and maintenance in hippocampal neurons |
| Long-term depression (LTD) | Involved in AMPA receptor internalization during LTD |
| NMDA receptor signaling | Interacts with NMDA receptor subunits to mediate activity-dependent signaling [@wang2011] |
| Associated Diseases | neurodegeneration |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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