| Gene Symbol | RPL6 |
| Full Name | Ribosomal Protein L6 |
| Chromosome | 12q24.31 |
| Protein Type | Ribosomal protein, 60S large subunit |
| Function | is a component of the 60S large ribosomal subunit and plays a critical role in protein synthesis within all eukaryotic cells, including neurons. |
| Molecular Weight | 32.5 kDa |
| UniProt ID | P62888 |
| NCBI Gene ID | 6128 |
| GeneCards | RPL6 |
| Human Protein Atlas | RPL6 |
| Peptidyl Transferase Activity | RPL6 contributes to the peptidyl transferase center (PTC) of the ribosome, where peptide bonds are formed between amino acids during protein synthesis |
| Ribosome Structure | RPL6 helps maintain the structural integrity of the 60S subunit, interacting with rRNA and other ribosomal proteins to form a stable functional ribosome |
| Translation Initiation | The 60S subunit joins the 40S pre-initiation complex to form the 80S ribosome, which is essential for the initiation of protein synthesis in eukaryotes |
| Translation Elongation | During the elongation phase, RPL6 participates in the translocation of tRNA molecules between the A, P, and E sites of the ribosome |
| Global Translation Impairment | Post-mortem brain studies of AD patients reveal decreased levels of ribosomal proteins and reduced translational capacity in affected brain regions, particularly the hippocampus and prefrontal cortex |
| Associated Diseases | neurodegeneration |
| Databases | GeneCardsHPASTRING |
No AI portrait yet
No comments yet. Be the first to comment!