| Gene Symbol | RPS14 |
| Chromosome | 5q |
| Function | encodes an essential ribosomal protein component of the 40S small ribosomal subunit. |
| Molecular Weight | 16 kDa |
| Amino Acids | 151 aa |
| Ensembl ID | ENSG00000129864 |
| GeneCards | RPS14 |
| Human Protein Atlas | RPS14 |
| rRNA binding and stabilization | RPS14 interacts with 18S rRNA, stabilizing the rRNA structure |
| mRNA binding | The protein participates in the mRNA entry channel, facilitating mRNA binding and scanning |
| Translation initiation | RPS14 contributes to the formation of the pre-initiation complex (43S PIC) |
| Small subunit assembly | Proper RPS14 incorporation is essential for 40S biogenesis |
| Haploinsufficiency | Most pathogenic RPS14 variants create null alleles, leading to reduced RPS14 protein levels |
| Impaired ribosome biogenesis | Reduced RPS14 availability compromises 40S ribosomal subunit assembly |
| Selective translational defect | Erythroid progenitor cells are particularly sensitive to ribosomal stress due to high translational demands |
| Associated Diseases | neurodegeneration |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |