| Gene Symbol | RRAGC |
| Function | Unlike classical Ras GTPases, Rag GTPases do not directly regulate cell proliferation but instead control the nutrient-sensitive mTORC1 pathway |
| Subcellular Localization | **Autophagy Regulation**
Rag GTPases are crucial regulators of autophagy:
- ** |
| Pathways | mTOR, MTOR |
| Ensembl ID | ENSG00000136244 |
| GeneCards | RRAGC |
| Human Protein Atlas | RRAGC |
| GTP-bound state | Active, promotes mTORC1 recruitment to lysosomes |
| GDP-bound state | Inactive, prevents mTORC1 signaling |
| GTPase cycle | Regulated by guanine nucleotide exchange factors (GEFs) and GTPase-activating proteins (GAPs) |
| Heterodimer formation | RRAGC forms heterodimers with RRAGA or RRAGB |
| Lysosomal recruitment | The Rag heterodimer recruits mTORC1 to the lysosomal surface where it is activated |
| Amino acid sensing | Rag GTPases sense amino acid levels in the lysosomal lumen |
| Ragulator complex | RRAGC interacts with the Ragulator complex (LAMTOR1-5) for proper localization |
| mTORC1 inhibition | Inactive Rag GTPases allow mTORC1 to release, enabling autophagy initiation |
| Associated Diseases | neurodegeneration |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |