| Gene Symbol | SCAR20 |
| Full Name | IQCA1 (IQ Motif Containing A) |
| Aliases | IQCA1 |
| Function | The discovery of SCAR20 as the causative gene for this syndrome provided important insights into the molecular pathways required for normal hearing development and cognitive function. |
| Subcellular Localization | Signals (NLS)**: Target the protein to the nucleus
- **Domain Architecture**: Th |
| Ensembl ID | ENSG00000165704 |
| GeneCards | SCAR20 |
| Human Protein Atlas | SCAR20 |
| IQ Motifs | Calcium-independent calmodulin-binding motifs that mediate protein-protein interactions |
| Coiled-coil Regions | Involved in protein oligomerization and complex formation |
| Nuclear Localization Signals (NLS) | Target the protein to the nucleus |
| Domain Architecture | The N-terminal region contains the IQ motifs, while the C-terminal portion includes regions for nuclear targeting and protein interactions |
| Nucleus | Predominantly nuclear localization, particularly in the nucleolus |
| Nucleolus | Enriched in the nucleolus, suggesting a role in ribosome biogenesis |
| Cytoplasm | Lower levels in the cytoplasm, potentially representing a pool for nuclear import |
| Associated Diseases | neurodegeneration |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |