gene 1,543 words KG: SCO2 2026-03-26
kind:genesection:genesstate:published
Contents

SCO2 — Cytochrome c Oxidase Assembly Factor SCO2

🧬 Gene Info
Gene SymbolSCO2
Full NameCytochrome c Oxidase Assembly Factor SCO2
AliasesComplex IV
Functionencodes a mitochondrial protein essential for the assembly of cytochrome c oxidase (COX), also known as Complex IV of the mitochondrial respiratory chain.
Subcellular Localizationthe mitochondrial matrix:
Molecular Weight29 kDa
Amino Acids262 aa
Ensembl IDENSG00000130489
GeneCardsSCO2
Human Protein AtlasSCO2
Inner membrane associationPartially associated with the inner membrane near assembly intermediates
Assembly complexesPart of larger COX assembly intermediates
OnsetPresents in the first months of life
SymptomsSevere cardiomyopathy, lactic acidosis, failure to thrive
OutcomeTypically fatal within the first year of life
Associated Diseasesneurodegeneration
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

Knowledge Graph

Related Hypotheses (3)

Matrix Stiffness Normalization via Targeted Lysyl Oxidase In
Score: 0.51
SIRT3-Mediated Mitochondrial Deacetylation Failure with PINK
Score: 0.51
Astrocytic Lactate Shuttle Enhancement for Grid Cell Bioener
Score: 0.41

Related Analyses (2)

Perivascular spaces and glymphatic clearance failure in AD
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

Related Experiments (13)

Animal Model Comparison for Neurodegenerative Disease Therap
clinical · proposed · Score: 0.40
Endocannabinoid System Dysfunction Validation in Parkinson's
clinical · proposed · Score: 0.40
Glymphatic-Circadian Axis Enhancement Therapy for Parkinson'
clinical · proposed · Score: 0.40
Cytochrome Therapeutics
clinical · proposed · Score: 0.40
Gut Microbiome-Derived Metabolites in Alpha-Synuclein Propag
clinical · proposed · Score: 0.40

See Also (1)

Neurodegeneration
disease · KG edge: implicated_in