| Gene Symbol | SEM1 |
| Function | SEM1 is a component of the 19S regulatory particle (PA700) of the 26S proteasome. The protein: |
| Subcellular Localization | to both nucleus and cytoplasm, with enrichment at the proteasome |
| GeneCards | SEM1 |
| Human Protein Atlas | SEM1 |
| Amyotrophic lateral sclerosis | Rare variants identified in ALS patients |
| Frontotemporal dementia | Altered expression in FTD brain tissue |
| Haploinsufficiency models | Reduced SEM1 leads to proteasome impairment |
| Associated Diseases | neurodegeneration |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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