| Gene Symbol | Septin 8 |
| Chromosome | 5q31.1 |
| Function | is a member of the septin family of GTP-binding proteins that play critical roles in cytoskeletal organization, membrane dynamics, and synaptic function. |
| Primary Expression | neurons and is enriched at synaptic terminals where it participates in synaptic vesicle trafficking and neurotransmitter release[ |
| UniProt ID | Q9UQD8 |
| NCBI Gene ID | 23176 |
| Ensembl ID | ENSG00000141504 |
| OMIM | 607410 |
| N-terminal polybasic region | Involved in membrane association through phosphatidylinositol phosphate binding |
| C-terminal coiled-coil domain | Mediates interaction with other septin subunits and binding partners |
| Cerebral cortex | Layer 5 pyramidal neurons show robust SEPTIN8 expression |
| Basal ganglia | Striatal medium spiny neurons |
| Cerebellum | Purkinje cells |
| Substantia nigra | Dopaminergic neurons |
| Associated Diseases | neurodegeneration |
| Databases | GeneCardsHPASTRING |
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