| Gene Symbol | SGSM1 |
| Aliases | Small G Protein Signaling Modulator 1 |
| Chromosome | 17p13.1 |
| Function | RAB GTPases cycle between an active GTP-bound state and an inactive GDP-bound state, and this cycling is precisely controlled by two families of regulatory proteins: guanine nucleotide exchange factor |
| Molecular Weight | 102 kDa |
| Amino Acids | 910 aa |
| Ensembl ID | ENSG00000156469 |
| GeneCards | SGSM1 |
| Human Protein Atlas | SGSM1 |
| Autophagic Flux | Through regulation of RAB proteins involved in autophagosome formation and maturation, SGSM1 influences the autophagy-lysosome pathway that is critical for neuronal homeostasis [6]. |
| Synaptic Vesicle Cycling | RAB3 and RAB27 family members regulate synaptic vesicle exocytosis and endocytosis. SGSM1 helps maintain the precise timing of vesicle cycling required for continuous neurotransmission [7]. |
| Receptor Trafficking | Regulation of RAB5 and RAB11 controls neurotrophin receptor (TrkB) and glutamate receptor (AMPA, NMDA) trafficking, affecting synaptic plasticity and neuronal survival [8]. |
| Associated Diseases | neurodegeneration |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |