| Gene Symbol | SLC24A1 |
| Full Name | Sodium/Calcium Exchanger 1 (NCKX1) |
| Function | This unique coupling allows for efficient calcium extrusion against steep concentration gradients, making it crucial for |
| Primary Expression | rod and cone photoreceptors where it mediates Ca2+ extrusion during light adaptation [2](https://pubmed |
| Amino Acids | 501 aa |
| UniProt ID | O60739 |
| Ensembl ID | ENSG00000100767 |
| GeneCards | SLC24A1 |
| Human Protein Atlas | SLC24A1 |
| Photoreceptor function | NCKX1 is highly expressed in rod and cone photoreceptors where it mediates Ca2+ extrusion during light adaptation 2 |
| Neuronal calcium regulation | Controls cytosolic Ca2+ levels in various neuronal populations |
| Synaptic plasticity | Calcium extrusion supports long-term potentiation and memory formation |
| Calcium dysregulation hypothesis | Aβ oligomers cause pathological Ca2+ influx through various channels |
| NCKX1 downregulation | Studies suggest reduced NCKX1 expression in AD brain 3 |
| Therapeutic potential | Enhancing NCKX1 function could improve Ca2+ extrusion |
| Associated Diseases | neurodegeneration |
| Databases | GeneCardsNCBI GeneHPASTRING |
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