| Gene Symbol | SLC30A1 |
| Aliases | ZnT1 |
| Function | ZnT1 plays a critical role in protecting cells from zinc toxicity while also ensuring adequate zinc supply for essential cellular functions. |
| Primary Expression | neurons, astrocytes, and the blood-brain barrier, where it contributes to zinc homeostasis in the [central nervous system](/brain-regions/central-nerv |
| Subcellular Localization | affects transport activity |
| Amino Acids | 501 aa |
| Ensembl ID | ENSG00000170370 |
| GeneCards | SLC30A1 |
| Human Protein Atlas | SLC30A1 |
| Six transmembrane domains | Form the transport channel |
| N- and C-terminal tails | Located in the cytoplasm |
| Histidine-rich loop | Between TM4 and TM5 (involved in zinc binding) |
| Dimerization | Functions as a homodimer 5 |
| Zinc-dependent | MTF-1 (metal-responsive transcription factor-1) activates transcription under zinc deficiency |
| Cellular zinc status | Zinc-responsive promoter elements control expression |
| Associated Diseases | neurodegeneration |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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