| Gene Symbol | TCF4-GENE |
| Aliases | TCF4_GENE |
| Chromosome | 18q21.2 |
| Protein Type | Transcription Factor |
| Function | is a basic helix-loop-helix (bHLH) transcription factor encoded by the TCF4 gene on chromosome 18q21. |
| Primary Expression | the developing brain, with persistent expression in adulthood particularly in:
- Hippocampal CA1-CA3 regions
- Cerebral cortex (layer 2/3 pyramidal ne |
| Amino Acids | 010 aa |
| Exons | 20 |
| GeneCards | TCF4-GENE |
| Human Protein Atlas | TCF4-GENE |
| Condition | Odds Ratio |
| Alzheimer's disease | 1.08-1.15 |
| Schizophrenia | 1.36-1.42 |
| Pitt-Hopkins syndrome | N/A |
| NEUROD1 | Heterodimer |
| Associated Diseases | Cancer, Carcinoma, Fuchs Endothelial Corneal Dystrophy, Pitt-Hopkins Syndrome, psychiatric disorders, schizophrenia |
| Known Drugs/Compounds | rapamycin |
| Interactions | MYC, FOXP3, MMP9, LAMP1, RAB7A, TCF7L2 |
| KG Connections | 159 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |