| Gene Symbol | TDP2 |
| Full Name | Tyrosyl-DNA Phosphodiesterase 2 |
| Chromosome | 6p22.3 |
| Protein Type | Enzyme |
| Function | is a critical DNA repair enzyme specialized in resolving topoisomerase II (TOP2)-induced DNA damage. |
| Molecular Weight | 40.5 kDa |
| Amino Acids | 362 aa |
| Exons | 9 |
| UniProt ID | [Q9H2P2](https://www.uniprot.org/uniprot/Q9H2P2) |
| Ensembl ID | ENSG00000111802 |
| OMIM | 614675 |
| GeneCards | TDP2 |
| Human Protein Atlas | TDP2 |
| Chemical inhibitors | Etoposide, doxorubicin, and anthracycline chemotherapeutics stabilize the cleavage complex |
| Endogenous stress | Reactive oxygen species (ROS) can oxidize TOP2, stabilizing its covalent linkage to DNA |
| Associated Diseases | neurodegeneration |
| Databases | GeneCardsNCBI GeneHPASTRING |