| Gene Symbol | TIC1 |
| Full Name | Transcriptional Intermediary Factor 1 |
| Chromosome | 2p23.3 |
| Protein Type | Receptor |
| Function | is a nuclear receptor coactivator that plays a critical role in transcriptional regulation. |
| UniProt ID | Q13448 |
| Ensembl ID | ENSG00000100994 |
| OMIM | 603484 |
| GeneCards | TIC1 |
| Human Protein Atlas | TIC1 |
| Nuclear receptor interaction | Binds to ligand-bound nuclear receptors including estrogen receptor (ER), progesterone receptor (PR), thyroid hormone receptor (TR), and retinoic acid receptor (RAR) |
| Histone acetylation recruitment | Recruits p300/CBP histone acetyltransferases to chromatin |
| Chromatin remodeling | Attracts SWI/SNF complexes for nucleosome displacement |
| Mediator complex recruitment | Facilitates interaction between transcription factors and RNA polymerase II |
| PAS domains (PAS-A, PAS-B) | Protein-protein interactions and signal sensing |
| Associated Diseases | neurodegeneration |
| Databases | GeneCardsNCBI GeneHPASTRING |
No AI portrait yet
No comments yet. Be the first to comment!