| Gene Symbol | UBE2B |
| Aliases | Page for UBE2B |
| Chromosome | 5q31.1 |
| Protein Type | Enzyme |
| Function | In neurons, proper UPS function is critical due to the post-mitotic nature of these cells, which cannot rely on cell division to eliminate damaged proteins. |
| Primary Expression | testis and is essential for male fertility |
| Molecular Weight | 17 kDa |
| Pathways | cascade: **E1-E2-E3 Cascade:** |
| UniProt ID | P62256 |
| NCBI Gene ID | 7329 |
| Ensembl ID | ENSG00000119009 |
| OMIM | 604385 |
| GeneCards | UBE2B |
| Human Protein Atlas | UBE2B |
| Translesion Synthesis | UBE2B-mediated PCNA ubiquitination allows DNA polymerases to bypass DNA lesions that would otherwise block replication [3]. |
| Associated Diseases | neurodegeneration |
| Databases | GeneCardsHPASTRING |
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