| Gene Symbol | UBXD5 |
| Full Name | UBX Domain Containing 5 |
| Chromosome | 19q13.42 |
| Function | ERAD adaptor, VCP/p97 regulator, aggresome targeting |
| Primary Expression | both excitatory and inhibitory neurons, as well as in glial cells including astrocytes and microglia |
| Subcellular Localization | aggresomes, which are microtubule-organizing centers for protein aggregate sequestration[@yang2019] |
| Amino Acids | 80 aa |
| UniProt ID | Q9NVA1 |
| NCBI Gene ID | 58515 |
| Ensembl ID | ENSG00000130413 |
| GeneCards | UBXD5 |
| Human Protein Atlas | UBXD5 |
| Substrate Recognition | UBXD5 can bind to polyubiquitinated substrates through interactions with ubiquitin chains[@wang2015] |
| VCP Recruitment | The UBX domain mediates direct interaction with VCP/p97, bringing substrates to the extraction machinery[@schuberth2008] |
| Processive Extraction | Works in concert with other ERAD components to extract substrates from the ER membrane |
| Associated Diseases | neurodegeneration |
| Databases | GeneCardsHPASTRING |
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