| Gene Symbol | VRK1 |
| Full Name | Vaccinia-Related Kinase 1 |
| Chromosome | 14q32.33 |
| Protein Type | Kinase |
| Function | VRK1 encodes a serine/threonine protein kinase belonging to the VRK (Vaccinia-Related Kinase) family. |
| UniProt ID | Q15818 |
| NCBI Gene ID | 7443 |
| Ensembl ID | ENSG00000100749 |
| OMIM | 604680 |
| GeneCards | VRK1 |
| Human Protein Atlas | VRK1 |
| Cell cycle regulation | VRK1 phosphorylates p53, Thr-18, which disrupts p53-MDM2 interaction |
| DNA damage response | phosphorylates CHK2 and ATM/ATR substrates |
| Chromatin condensation | VRK1 phosphorylates histone H3 (Ser-10) and BAF (barrier-to-autointegration factor) |
| Neuronal development | regulates neurite outgrowth and neuronal differentiation |
| Associated Diseases | neurodegeneration |
| Databases | GeneCardsHPASTRING |
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