| Gene Symbol | WDR45L |
| Full Name | WD Repeat Domain 45 Like |
| Chromosome | 5q13.2 |
| Function | WDR45L is a WD40 repeat protein that functions in the autophagy pathway, specifically in the formation of autophagosomes from omegasomes |
| UniProt ID | [Q5JWC1](https://www.uniprot.org/uniprot/Q5JWC1) |
| Ensembl ID | ENSG00000147065 |
| GeneCards | WDR45L |
| Human Protein Atlas | WDR45L |
| WD40 repeats | Seven WD40 repeat domains that form a beta-propeller structure |
| PI3P-binding site | Mediates recruitment to PI3P-rich membranes |
| ATG2A/B binding region | Interacts with ATG2 proteins for lipid transfer |
| Selective autophagy | Involved in mitophagy and pexophagy |
| ER-phagy | Regulates ER turnover via ER-phagy |
| Lipid droplet autophagy | Participates in lipophagy |
| Phenotype | Childhood static encephalopathy with adult-onset neurodegeneration |
| Associated Diseases | neurodegeneration |
| Databases | GeneCardsNCBI GeneHPASTRING |