| Gene Symbol | XLF |
| Function | is a human gene whose product xLF (also known as NHEJ factor X or Cernunnos) is a core DNA non-homologous end joining (NHEJ) repair protein essential for V(D)J recombination and DSB repair[@ahnesor... |
| GeneCards | XLF |
| Human Protein Atlas | XLF |
| DNA end bridging | XLF homodimers tether blunt DNA ends together[@li2008] |
| V(D)J recombination | Essential for antigen receptor gene rearrangement in lymphocytes[@callebaut2006] |
| XRCC4-LIG4 recruitment | Directs ligase IV complex to DNA ends[@hentges2006] |
| Loop formation | Generates DNA loop structures facilitating repair[@lu2007] |
| SCID with microcephaly | Biallelic XLF mutations cause severe combined immunodeficiency with growth retardation[@buck2006] |
| radiosensitive SCID | Cellular sensitivity to ionizing radiation[@du2008] |
| Lymphoma | XLF variants in some B-cell malignancies[@liu2012] |
| Solid tumors | Altered expression in various cancers[@saito2011] |
| Alzheimer's disease | NHEJ components dysregulated in AD neurons; impaired DSB repair[@madsen2011] |
| Ataxia-telangiectasia | Overlapping phenotype with ATM deficiency[@stewart2009] |
| Cancer therapy | XLF as target for radiosensitization[@neal2015] |
| Associated Diseases | neurodegeneration |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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