gene 1,876 words KG: LGI2 2026-03-27
kind:genesection:genesstate:published
Contents

LGI2 — Leucine-Rich Glioma Inactivated 2

🧬 Gene Info
Gene SymbolLGI2
Full NameLeucine-Rich Glioma Inactivated 2
Chromosome4p15.2
Functionis a secreted neuronal protein that belongs to the LGI family of leucine-rich repeat (LRR) domain-containing proteins.
Primary Expressionthe brain, particularly in the hippocampus and cerebral cortex
Subcellular Localizationpresynaptic terminals, where it may function in axonal guidance and presynaptic organization [Citation 6]
Amino Acids509 aa
Exons10
GeneCardsLGI2
Human Protein AtlasLGI2
ProteinBrain Expression
LGI1Highest in cortex, hippocampus
LGI2Moderate, region-specific
LGI3Broad
LGI4Limited (oligodendrocytes)
Associated Diseasesneurodegeneration
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

Knowledge Graph