gene 663 words KG: GOLGA8FTLDFET
Contents

GOLGA8: A New FTLD-FET Gene with Dinucleotide Repeat Expansion

🧬 Gene Info
Gene SymbolGOLGA8FTLDFET
Functionis a spectrum of neurodegenerative diseases characterized by abnormal protein aggregates containing FET family proteins (FUS), TAF15, and EWS.
Primary Expressionneuronal tissues and is localized to the Golgi apparatus, where it plays a role in protein sorting and trafficking
Subcellular Localizationthe Golgi apparatus, where it plays a role in protein sorting and trafficking
GeneCardsGOLGA8FTLDFET
Human Protein AtlasGOLGA8FTLDFET
GeneGOLGA8 (GOLGA8A/GOLGA8B)
VariantCT dinucleotide repeat expansion in intron
Statistical Strengthp = 5.8 × 10⁻²¹, making this one of the strongest genetic associations for a sporadic neurodegenerative disease[@rosa2026]
Associated Diseasesneurodegeneration
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

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