| Gene Symbol | HTR5APROTEIN |
| Chromosome | 7q36.3 |
| Protein Type | Receptor |
| Function | is a Gi/o protein-coupled serotonin receptor that inhibits adenylyl cyclase, reducing intracellular cAMP production. |
| Primary Expression | trigeminal pain pathways, suggesting a role in migraine pathophysiology |
| Subcellular Localization | </b></td><td>Cell membrane, plasma membrane</td></tr> |
| Molecular Weight | 42 kDa |
| Amino Acids | 357 aa |
| GeneCards | HTR5APROTEIN |
| Human Protein Atlas | HTR5APROTEIN |
| Sleep induction | Activation of 5-HT5A receptors promotes sleep onset and increases total sleep time |
| Sleep consolidation | The receptor helps synchronize sleep-wake cycles through interactions with the suprachiasmatic nucleus |
| REM sleep modulation | Evidence suggests 5-HT5A modulates REM sleep patterns |
| Circadian rhythm | Receptor expression shows circadian variation, peaking during sleep-relevant hours |
| Learning and memory | Receptor activation influences hippocampal-dependent learning tasks |
| Associated Diseases | neurodegeneration |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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