| Gene Symbol | IBA57 |
| Function | is an important component in the neurobiology of neurodegenerative diseases. |
| Primary Expression | tissues with high mitochondrial content: |
| Molecular Weight | 40 kDa |
| Ensembl ID | ENSG00000169189 |
| GeneCards | IBA57 |
| Human Protein Atlas | IBA57 |
| Fe-S Cluster Biogenesis | Essential cofactor for ISCA2 and ISCA1 in the mitochondrial Fe-S cluster (ISC) assembly pathway[@beilschmidt2017] |
| Mitochondrial Electron Transport Chain | Required for proper assembly and function of Complex I (NADH:ubiquinone oxidoreductase), Complex II (succinate dehydrogenase), and Complex III (cytochrome bc1 complex) |
| Iron-Sulfur Protein Maturation | Catalyzes insertion of 4Fe-4S clusters into specific target proteins including aconitase, ferredoxin, and respiratory complex subunits |
| Mitochondrial DNA Maintenance | Indirectly supports mtDNA replication and transcription through Fe-S protein function |
| Cellular Iron Homeostasis | Regulates mitochondrial iron uptake and storage to prevent oxidative damage |
| Brain | High expression in cerebral cortex, hippocampus, basal ganglia, and spinal cord motor neurons |
| Skeletal Muscle | Essential for mitochondrial function in muscle fibers |
| Heart | Cardiac muscle relies heavily on oxidative phosphorylation |
| Associated Diseases | neurodegeneration |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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