idea 2,114 words KG: ent-gene-16cf4081 2026-03-24
kind:ideakind:therapy-ideasection:ideasstate:published
Contents

CSF1R-Targeted Microglia Therapy

🔬 Protein Info
Gene SymbolCSF1R
Full NameTargeted Microglia Therapy
AliasesColony Stimulating Factor 1 Receptor
Chromosome5q32
Protein TypeReceptor
FunctionControls microglial survival, proliferation, and differentiation
Primary ExpressionMicroglia, Macrophages, Osteoclasts, Placenta
Molecular Weight107.6 kDa
Amino Acids972 aa
PathwaysPI3K
UniProt IDP07333
NCBI Gene ID1436
Ensembl IDENSG00000182578
OMIM164770
GeneCardsCSF1R
Human Protein AtlasCSF1R
Associated DiseasesALS, Alzheimer, Anxiety, Atherosclerosis, CSF1R-related Leukoencephalopathy
Known Drugs/CompoundsKETAMINE, NICOTINAMIDE, PLX3397, PLX5622, nicotinamide, dasatinib
InteractionsSTAT5, MECP2, JAK2, PDGFRB, BDNF, CX3CR1
KG Connections586 knowledge graph edges
DatabasesGeneCardsHPASTRING

Knowledge Graph

Related Hypotheses (30)

Bacterial Enzyme-Mediated Dopamine Precursor Synthesis
Score: 0.36
TREM2-CSF1R Cross-Talk in Microglial Metabolic Reprogramming
Score: 0.59
TREM2-Dependent Astrocyte-Microglia Cross-talk in Neurodegen
Score: 0.64
TREM2-Mediated Astrocyte-Microglia Cross-Talk in Neurodegene
Score: 0.61
TREM2-mediated microglial tau clearance enhancement
Score: 0.49

Related Analyses (30)

Neuroinflammation and microglial priming in early Alzheimer'
neurodegeneration · archived
TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
APOE4 structural biology and therapeutic targeting strategie
neurodegeneration · archived
Autophagy-lysosome pathway convergence across neurodegenerat
neurodegeneration · archived
Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived

Related Experiments (6)

Proposed experiment from debate on Synaptic pruning by micro
falsification · proposed · Score: 0.40
ER-Golgi Secretory Pathway Dysfunction in PD - Experiment De
clinical · proposed · Score: 0.40
FTD Microglia Role: Protective vs Destructive Mechanism Stud
validation · proposed · Score: 0.40
Microglial TREM2 Agonist In Vivo Efficacy
validation · proposed · Score: 0.40
TREM2 Agonist Therapy for Parkinson's Disease — Experimental
validation · proposed · Score: 0.40