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RA Capital Management

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Related Hypotheses (11)

Cell-Type Specific TREM2 Upregulation in DAM Microglia
Score: 0.76APOE-TREM2 Interaction Modulation
Score: 0.74TREM2-Dependent Microglial Senescence Transition
Score: 0.62TREM2-Mediated Selective Aggregate Clearance Pathway
Score: 0.58TREM2 Conformational Stabilizers for Synaptic Discrimination
Score: 0.69TREM2-mediated microglial tau clearance enhancement
Score: 0.62Perforant Path Presynaptic Terminal Protection Strategy
Score: 0.70Reelin-Mediated Cytoskeletal Stabilization Protocol
Score: 0.69LRP1-Dependent Tau Uptake Disruption
Score: 0.60Extracellular Vesicle Biogenesis Modulation
Score: 0.58Tau-Independent Microtubule Stabilization via MAP6 Enhanceme
Score: 0.57

Related Analyses (5)

Selective vulnerability of entorhinal cortex layer II neuron
neurodegeneration · archivedProtein aggregation cross-seeding across neurodegenerative d
neurodegeneration · completedMechanistic role of APOE in neurodegeneration
neurodegeneration · archivedSynaptic pruning by microglia in early AD
neurodegeneration · archivedTau propagation mechanisms and therapeutic interception poin
neurodegeneration · archived

Related Experiments (1)

Macroautophagy Dysfunction in PD - Experiment Design
clinical · proposed · Score: 0.40

Knowledge Graph (8 edges)

RAB7A associated_with neurodegeneration
TRAF6 associated_with MTOR
STX17 co_discussed RAB7A
CHMP2B co_discussed RAB7A
LAMP1 co_discussed RAB7A
MCOLN1 co_discussed RAB7A
FOXO1 co_discussed RAB7A
IGF2R co_discussed RAB7A

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