| Gene Symbol | IRISIN |
| Aliases | IRISINPROTEIN |
| Function | Irisin acts as a systemic mediator, conveying the benefits of exercise to distant tissues including the brain. |
| Molecular Weight | ~12 kDa |
| Amino Acids | 112 aa |
| Pathways | Mitochondrial Function, Synaptic Plasticity |
| UniProt ID | Q8IZF6 |
| GeneCards | IRISIN |
| Human Protein Atlas | IRISIN |
| Precursor | FNDC5 |
| Length | 112 amino acids (mature) |
| Source Tissue | Skeletal muscle |
| Receptor | Ī±VĪ²5 integrin |
| Serum Concentration | 10-100 ng/mL |
| Half-life | ~1 hour |
| Associated Diseases | Alzheimer'S Disease, DIABETES, Insulin Sensitivity, Neurodegenerative Diseases, OBESITY, Osteoporosis |
| Interactions | AMPK, NFKB, FGF2, NEPRILYSIN, AMYLOID, IL-8 |
| KG Connections | 80 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |