disease

Alzheimer'S Disease

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about Alzheimer'S Disease: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

12228Connections

17Hypotheses

27Analyses

50Outgoing

50Incoming

No summary available yet. View on Wiki →

Disease Info

Associated Genes	SNCA, GJA1, MDK, PTN, NTN1, SMOC1, GPNMB, NPTX2
Therapeutic Agents	CI-994, Β-Sitosterol, Aducanumab, Cholinesterase Inhibitors, Memantine, Bispecific Antibodies
SciDEX Hypotheses	70 hypotheses
KG Connections	1546 knowledge graph edges
Databases	OMIM Orphanet ClinicalTrials PubMed

Wiki Pages (20)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    Alzheimer_S_Disease["Alzheimer'S Disease"] -->|"involved in"| Pathogenic_Mechanisms["Pathogenic Mechanisms"]
    style Pathogenic_Mechanisms fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
    Alzheimer_S_Disease["Alzheimer'S Disease"] -->|"causes"| Cognitive_Decline["Cognitive Decline"]
    style Cognitive_Decline fill:#1a2a3a,stroke:#ffd54f,stroke-width:1px,color:#fff
    Alzheimer_S_Disease["Alzheimer'S Disease"] -->|"associated"| Sleep_Disruption["Sleep Disruption"]
    style Sleep_Disruption fill:#1a2a3a,stroke:#ffd54f,stroke-width:1px,color:#fff
    Alzheimer_S_Disease["Alzheimer'S Disease"] -->|"associated"| Genetics["Genetics"]
    style Genetics fill:#1a2a3a,stroke:#ffd54f,stroke-width:1px,color:#fff
    Alzheimer_S_Disease["Alzheimer'S Disease"] -->|"causes"| Memory_Deficits["Memory Deficits"]
    style Memory_Deficits fill:#1a2a3a,stroke:#ffd54f,stroke-width:1px,color:#fff
    Alzheimer_S_Disease["Alzheimer'S Disease"] -->|"causes"| Learning_Deficits["Learning Deficits"]
    style Learning_Deficits fill:#1a2a3a,stroke:#ffd54f,stroke-width:1px,color:#fff
    Alzheimer_S_Disease["Alzheimer'S Disease"] -->|"causes"| Cognitive_Impairment["Cognitive Impairment"]
    style Cognitive_Impairment fill:#1a2a3a,stroke:#ffd54f,stroke-width:1px,color:#fff
    GJA1["GJA1"] -->|"associated"| Alzheimer_S_Disease["Alzheimer'S Disease"]
    style GJA1 fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
    Amyloid_Beta["Amyloid-Beta"] -->|"contributes to"| Alzheimer_S_Disease["Alzheimer'S Disease"]
    style Amyloid_Beta fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
    Tau["Tau"] -->|"contributes to"| Alzheimer_S_Disease["Alzheimer'S Disease"]
    style Tau fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
    Bispecific_Antibodies["Bispecific Antibodies"] -->|"treats"| Alzheimer_S_Disease["Alzheimer'S Disease"]
    style Bispecific_Antibodies fill:#1a2a3a,stroke:#81c784,stroke-width:1px,color:#fff
    Amyloid_Beta_1["Amyloid Beta"] -->|"causes"| Alzheimer_S_Disease["Alzheimer'S Disease"]
    style Amyloid_Beta_1 fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
    style Alzheimer_S_Disease fill:#ef5350,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0,font-weight:bold

Outgoing (5085)

Target	Relation	Type	Str
Pathogenic Mechanisms	involved_in	mechanism	0.95
Cognitive Decline	causes	phenotype	0.95
Neurodegeneration	causes	process	0.95
Neuroinflammation	associated_with	process	0.95
TAU	associated_with	protein	0.95
Dementia	causes	disease	0.95
Neurodegeneration	associated_with	process	0.95
Gene Mutations	associated_with	mechanism	0.95
Amyloid Beta	associated_with	protein	0.95
Dementia	associated_with	disease	0.95
Long-Term Potentiation	associated_with	process	0.95
Tau Tangles	associated_with	biomarker	0.95
Microglia	associated_with	cell_type	0.95
Neuronal Loss	causes	phenotype	0.95
Amyloid-Beta Aggregation	involved_in	process	0.95
Cellular Senescence	associated_with	process	0.95
Sleep Disruption	associated_with	phenotype	0.90
Genetics	associated_with	process	0.90
Astrocyte Imbalance	associated_with	phenotype	0.90
Viral Vector Gene Therapy	treats	drug	0.90
Brain Structure	causes	phenotype	0.90
Cognition	causes	phenotype	0.90
Neuronal Death	causes	phenotype	0.90
Apoptosis	associated_with	process	0.90
Sleep Disturbance	causes	phenotype	0.90
Related Dementias	associated_with	disease	0.90
Blood-Brain Barrier	causes	process	0.90
Parvalbumin-Containing Interneurons	downregulates	cell_type	0.90
Nrg1-Erbb4 Signaling	associated_with	pathway	0.90
Disease-Associated Microglia	associated_with	cell_type	0.90
Proteinopathies	associated_with	mechanism	0.90
Pathology Accumulation	associated_with	process	0.90
Brain Blood Flow Regulation	associated_with	process	0.90
Synaptic Dysfunction	causes	process	0.90
anxiety	associated_with	disease	0.90
Memory Deficits	causes	phenotype	0.85
Learning Deficits	causes	phenotype	0.85
Cognitive Impairment	causes	phenotype	0.85
MICROGLIA	activates	cell_type	0.85
Neurocognitive Disorders	associated_with	disease	0.85
Atherosclerosis	associated_with	disease	0.85
Synaptic Transmission	associated_with	process	0.85
Disease-Associated Microglia	causes	phenotype	0.85
Microglial Heterogeneity	modulates	phenotype	0.85
Neurons	targets	cell_type	0.85
Middle Temporal Gyrus	associated_with	brain_region	0.85
Heterogeneous Molecular Changes	associated_with	process	0.80
Tissue Stiffness	causes	biomarker	0.80
Neurogenesis	causes	process	0.80
Memory Performance	causes	phenotype	0.75

Incoming (7143)

Source	Relation	Type	Str
GJA1	associated_with	gene	0.95
Amyloid-Beta	contributes_to	protein	0.95
Tau	contributes_to	protein	0.95
Bispecific Antibodies	treats	drug	0.95
Amyloid Beta	causes	protein	0.95
Tau	causes	protein	0.95
Blood-Based Biomarkers	biomarker_for	biomarker	0.95
Rg1	treats	compound	0.95
Amyloid Beta	contributes_to	protein	0.95
Astrocyte	involved_in	cell_type	0.95
Oligodendrocyte	involved_in	cell_type	0.95
Gut Microbiota	associated_with	process	0.95
APP	causes	gene	0.95
PSEN1	causes	gene	0.95
PSEN2	causes	gene	0.95
Neurofibrillary Tangles	biomarker_for	biomarker	0.95
Amyloid Plaque	biomarker_for	biomarker	0.95
MAPT	biomarker_for	protein	0.95
APP	biomarker_for	protein	0.95
HAVCR2	associated_with	gene	0.95
MST1	targets	gene	0.95
Neuroinflammation	involved_in	process	0.95
Amyloid-Β	biomarker_for	biomarker	0.95
Cyclosporine A	modulates	drug	0.95
SORL1	risk_factor_for	gene	0.95
APOE4	risk_factor_for	gene	0.95
SYN1	associated_with	protein	0.95
Honokiol	treats	compound	0.95
Stem Cell Therapies	treats	process	0.95
Atherosclerosis	risk_factor_for	disease	0.95
Genetic Variation	associated_with	mechanism	0.95
Amyloid-Beta	associated_with	protein	0.95
TAU	associated_with	protein	0.95
YKL-40	biomarker_for	protein	0.95
Amyloid Beta Deposition	associated_with	mechanism	0.95
Tau Tangle Formation	associated_with	mechanism	0.95
Bd-Tau	biomarker_for	biomarker	0.95
Amyloid-Β	contributes_to	compound	0.95
HDAC3	involved_in	gene	0.95
MAPT	associated_with	gene	0.95
Diabetes Mellitus	associated_with	disease	0.95
Glymphatic System	involved_in	process	0.95
Parthanatos	involved_in	pathway	0.95
Brain Aging	risk_factor_for	process	0.95
SIRT3	associated_with	gene	0.95
PPARGC1A	downregulates	gene	0.95
TDP-43	biomarker_for	protein	0.95
Ageing	risk_factor_for	process	0.95
Amyloid Plaques	biomarker_for	biomarker	0.95
Tau Pathology	biomarker_for	phenotype	0.95

Targeting Hypotheses (17)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Closed-loop transcranial focused ultrasound to restore hippo	0.709	Alzheimer's disease	Circuit-level neural dynamics in neurode
Closed-loop transcranial focused ultrasound with 40Hz gamma	0.689	Alzheimer's disease	Circuit-level neural dynamics in neurode
Closed-loop transcranial focused ultrasound to restore hippo	0.633	Alzheimer's disease	Circuit-level neural dynamics in neurode
Closed-loop transcranial focused ultrasound targeting EC-II	0.633	Alzheimer's disease	Circuit-level neural dynamics in neurode
Closed-loop tACS targeting entorhinal cortex layer II SST in	0.625	Alzheimer's disease	Circuit-level neural dynamics in neurode

Closed-loop transcranial focused ultrasound to restore hippo	0.614	Alzheimer's disease	Circuit-level neural dynamics in neurode
Closed-loop transcranial focused ultrasound targeting EC-II	0.612	Alzheimer's disease	Circuit-level neural dynamics in neurode
Optogenetic restoration of hippocampal gamma oscillations vi	0.566	Alzheimer's disease	Circuit-level neural dynamics in neurode
Optogenetic viral vector delivery via tFUS-mediated blood-br	0.557	Alzheimer's disease	Circuit-level neural dynamics in neurode
Optogenetic restoration of hippocampal gamma oscillations vi	0.554	Alzheimer's disease	Circuit-level neural dynamics in neurode
ACSL4-Ferroptotic Priming in Stressed Oligodendrocytes Drive	0.512	Alzheimer's Disease	Cell type vulnerability in Alzheimers Di
Closed-loop transcranial focused ultrasound targeting CA1 PV	0.508	Alzheimer's disease	Circuit-level neural dynamics in neurode
Microglial TREM2 downregulation impairs damage-associated re	0.507	Alzheimer's disease	SEA-AD Single-Cell Analysis: Cell-Type V
GAS6/TAM Axis Activation Stabilizes Blood-Brain Barrier to R	0.498	neuroinflammation	Why do TAM receptors protect against neu
C1QA/C1QB Subunit-Specific Inhibition to Block Aberrant PV I	0.497	neurodegeneration	Are interneuron oscillation deficits com
ACSL4-Driven Ferroptotic Priming in Disease-Associated Oligo	0.493	Alzheimer's Disease	Cell type vulnerability in Alzheimers Di
Epigenetic Memory Reprogramming for Alzheimer's Disease	0.467	neurodegeneration	CRISPR-based therapeutic approaches for

Mentioning Analyses (27)

Scientific analyses that reference this entity

What molecular mechanisms mediate SPP1-induced microglial phagocytic activation

neuroinflammation | 2026-04-15 | 1 hypotheses Top: 0.650

What are the physiological functions of BACE1 beyond APP processing that could c

neurodegeneration | 2026-04-15 | 1 hypotheses Top: 0.527

What molecular mechanisms mediate HDAC9's effects on Aβ deposition and synaptic

neurodegeneration | 2026-04-15 | 1 hypotheses Top: 0.578

What molecular mechanisms mediate HDAC9's effects on Aβ deposition and synaptic

neurodegeneration | 2026-04-14 | 0 hypotheses

What signals trigger microglia to specifically recognize and phagocytose LC axon

neuroinflammation | 2026-04-14 | 0 hypotheses

Related Papers (20)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year
External fixation versus reverse shoulder arthroplasty for proximal humerus frac [PMID:41940987]	Vadalà A, Benelli C, Suraci F, Carta B,	Arch Orthop Trauma Surg	2026
Gray matter structural and molecular signatures in Alzheimer's disease and late- [PMID:41419068]	Yang S, Wang X, Yan Y, Zhang J, Wei Y et	J Affect Disord	2026
Cytomegalic parvalbumin neurons in fetal cases of hemimegalencephaly. [PMID:39973610]	Gelot AB, Draia-Nicolau TO, Mathieu R, S	Epilepsia	2025
Brain connectivity and transcriptional changes induced by rTMS in first-episode [PMID:40274783]	Guan M, Xie Y, Wang Z, Miao Y, Li X et a	Transl Psychiatry	2025
Single-cell RNA sequencing of adult primate neocortex reveals the regulatory dyn [PMID:40385068]	Zhang C, Xie Z, Wang N	Am J Transl Res	2025
Human stem cell-derived GABAergic interneuron development reveals early emergenc [PMID:40651475]	Bershteyn M, Zhou H, Fuentealba L, Chen	Neuron	2025
Enhancer AAV toolbox for accessing and perturbing striatal cell types and circui [PMID:40403704]	Hunker AC, Wirthlin ME, Gill G, Johansen	Neuron	2025
Forebrain assembloids support the development of fast-spiking human PVALB+ corti [PMID:40695284]	Walsh RM, Crabtree GW, Kalpana K, Jubier	Neuron	2025
Anterior cingulate cortex parvalbumin and somatostatin interneurons shape social [PMID:40320404]	Qi C, Sima W, Mao H, Hu E, Ge J et al.	Nat Commun	2025
Distinct dendritic integration strategies control dynamics of inhibition in the [PMID:40592329]	Morabito A, Zerlaut Y, Dhanasobhon D, Be	Neuron	2025
Targeting SARM1 improves autophagic stress-induced axonal neuropathy. [PMID:37561040]	Kim HR, Lee HJ, Jeon Y, Jang SY, Shin YK	Autophagy	2024
Integrated multimodal cell atlas of Alzheimer's disease. [PMID:39402379]	Gabitto MI, Travaglini KJ, Rachleff VM,	Nat Neurosci	2024
Identification of early Alzheimer's disease subclass and signature genes based o [PMID:39650656]	Wang W, Lu J, Pan N, Zhang H, Dai J et a	Front Immunol	2024
Cortical somatostatin long-range projection neurons and interneurons exhibit div [PMID:38086373]	Fisher J, Verhagen M, Long Z, Moissidis	Neuron	2024
Locus Coeruleus-Dorsolateral Septum Projections Modulate Depression-Like Behavio [PMID:38155473]	Zhang Q, Xue Y, Wei K, Wang H, Ma Y et a	Adv Sci (Weinh)	2024
Somatostatin and the pathophysiology of Alzheimer's disease. [PMID:38484981]	Almeida VN	Ageing Res Rev	2024
Somatostatin interneurons control the timing of developmental desynchronization [PMID:38599213]	Mòdol L, Moissidis M, Selten M, Oozeer F	Neuron	2024
De novo gene synthesis by an antiviral reverse transcriptase. [PMID:39116258]	Tang S, Conte V, Zhang DJ, Žedaveinytė R	Science	2024
Signature morphoelectric properties of diverse GABAergic interneurons in the hum [PMID:37824669]	Lee BR, Dalley R, Miller JA, Chartrand T	Science	2023
Novel App knock-in mouse model shows key features of amyloid pathology and revea [PMID:35690868]	Xia D, Lianoglou S, Sandmann T, Calvert	Mol Neurodegener	2022

Alzheimer'S Disease

Understanding Entity Pages

Wiki Pages (20)

cbs-psp-daily-action-plan

Personalized Treatment Plan — Atypical Parkinsonism (CBS/PSP)

Progressive Supranuclear Palsy (PSP)

Corticobasal Syndrome (CBS)

Novel Therapy Index

Parkinson's Disease

Sleep and Circadian Dysfunction in Alzheimer's Disease

Microglia CD8+ T Cell Recruitment -- Supplementary WW Content

primary-progressive-aphasia

CBS/PSP Supplements Guide

Atypical Parkinsonism

Device Therapies Comparison for CBS/PSP

Parthanatos in Neurodegeneration

calcium-dysregulation-comparison

Alpha-Synuclein Pathology

Myoclonus and Cortical Hyperexcitability in Corticobasal Syndrome