disease

DIABETES

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about DIABETES: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

3248Connections

0Hypotheses

1Analyses

50Outgoing

50Incoming

No summary available yet. View on Wiki →

Disease Info

NCT Number	NCT07083154
Status	Recruiting
Phase	Phase 3
Enrollment	420 participants (estimated)
Study Type	Interventional
Allocation	Randomized, parallel-group
Intervention Model	Double-blind, placebo-controlled
Start Date	September 27, 2025
Completion Date	August 1, 2029
Primary Outcome	Integrated Alzheimer's Disease Rating Scale (iADRS) Score Change[@iadrsscale]
Sponsor	The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School
Associated Genes	STAT3, EGFR, TREM2, NRF2, MTOR, TAU, NF-KB, GFAP
KG Connections	571 knowledge graph edges
Databases	OMIM Orphanet ClinicalTrials PubMed

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    DIABETES["DIABETES"] -->|"causes"| NEUROPATHY["NEUROPATHY"]
    style NEUROPATHY fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#e0e0e0
    DIABETES["DIABETES"] -->|"increases"| GFAP["GFAP"]
    style GFAP fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#e0e0e0
    DIABETES["DIABETES"] -->|"protects against"| MICROGLIA["MICROGLIA"]
    style MICROGLIA fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    DIABETES["DIABETES"] -->|"causes"| MITOCHONDRIAL_DYSFUNCTION["MITOCHONDRIAL DYSFUNCTION"]
    style MITOCHONDRIAL_DYSFUNCTION fill:#1a2a3a,stroke:#ffd54f,stroke-width:1px,color:#e0e0e0
    DIABETES["DIABETES"] -->|"causes"| MITOPHAGY["MITOPHAGY"]
    style MITOPHAGY fill:#1a2a3a,stroke:#ffd54f,stroke-width:1px,color:#e0e0e0
    DIABETES["DIABETES"] -->|"protects against"| OXIDATIVE_STRESS["OXIDATIVE STRESS"]
    style OXIDATIVE_STRESS fill:#1a2a3a,stroke:#ffd54f,stroke-width:1px,color:#e0e0e0
    DIABETES["DIABETES"] -->|"regulates"| TUMOR["TUMOR"]
    style TUMOR fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#e0e0e0
    CLOCK["CLOCK"] -->|"associated"| DIABETES["DIABETES"]
    style CLOCK fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    BMAL1["BMAL1"] -->|"associated"| DIABETES["DIABETES"]
    style BMAL1 fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    ACHE["ACHE"] -->|"protects against"| DIABETES["DIABETES"]
    style ACHE fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#e0e0e0
    ALZHEIMER["ALZHEIMER"] -->|"increases"| DIABETES["DIABETES"]
    style ALZHEIMER fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#e0e0e0
    ALZHEIMER_S["ALZHEIMER'S"] -->|"increases"| DIABETES["DIABETES"]
    style ALZHEIMER_S fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#e0e0e0
    style DIABETES fill:#ef5350,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0,font-weight:bold

Outgoing (1088)

Target	Relation	Type	Str
OBESITY	interacts_with	disease	0.80
TYPE 2 DIABETES	increases_risk	disease	0.70
LIPID METABOLISM	interacts_with	phenotype	0.70
NEUROPATHY	causes	disease	0.65
NEUROPATHY	treats	disease	0.65
GFAP	increases	gene	0.65
MICROGLIA	protects_against	cell_type	0.65
TUMOR	regulates	disease	0.65
NEURODEGENERATION	promotes	disease	0.65
OBESITY	increases	disease	0.65
MONOCYTE	expressed_in	cell_type	0.65
MONOCYTES	expressed_in	cell_type	0.65
MONOCYTE	causes	cell_type	0.65
MONOCYTES	causes	cell_type	0.65
RAS	reduces	gene	0.65
MICROGLIA	increases	cell_type	0.65
HYPERTENSION	interacts_with	disease	0.65
METFORMIN	contributes_to	drug	0.65
OBESITY	impairs	disease	0.65
NEUROPATHY	impairs	disease	0.65
QUERCETIN	causes	drug	0.65
METFORMIN	treats	drug	0.65
QUERCETIN	treats	drug	0.65
NEUROPATHY	increases_risk	disease	0.65
METFORMIN	targets	drug	0.65
MACROPHAGE	causes	cell_type	0.65
ALZHEIMER'S DISEASE	increases_risk	disease	0.65
DEMENTIA	increases_risk	disease	0.65
IMMUNE SURVEILLANCE	interacts_with	phenotype	0.65
IMMUNE SURVEILLANCE	inhibits	phenotype	0.65
ATHEROSCLEROSIS	exacerbates	disease	0.65
AGING	exacerbates	phenotype	0.65
P2RX7	protects_against	gene	0.60
STING	protects_against	gene	0.60
OBESITY	causes	disease	0.60
MACROPHAGE	exacerbates	cell_type	0.60
MACROPHAGES	exacerbates	cell_type	0.60
NEUTROPHIL	exacerbates	cell_type	0.60
SIRT6	regulates	gene	0.60
MACROPHAGE	regulates	cell_type	0.60
MACROPHAGE	treats	cell_type	0.60
MACROPHAGES	treats	cell_type	0.60
LDLR	expressed_in	gene	0.60
MACROPHAGE	expressed_in	cell_type	0.60
MACROPHAGES	expressed_in	cell_type	0.60
NEURODEGENERATION	causes	disease	0.60
NEURON	causes	cell_type	0.60
STING	associated_with	gene	0.60
NEURODEGENERATION	contributes_to	disease	0.60
MTOR	contributes_to	gene	0.60

Incoming (2160)

Source	Relation	Type	Str
CLOCK	associated_with	entity	0.80
BMAL1	associated_with	entity	0.80
DEMENTIA	regulates	disease	0.70
ACSL4	inhibits	gene	0.70
ACHE	protects_against	gene	0.65
ALZHEIMER	increases	disease	0.65
ALZHEIMER'S	increases	disease	0.65
ALZHEIMER'S DISEASE	increases	disease	0.65
ATHEROSCLEROSIS	expressed_in	disease	0.65
DEMENTIA	reduces	disease	0.65
CANCER	treats	disease	0.65
ASTROCYTE	increases	cell_type	0.65
ATHEROSCLEROSIS	associated_with	disease	0.65
INFLAMMATION	targets	phenotype	0.65
MITOPHAGY	targets	phenotype	0.65
NEURON	treats	cell_type	0.65
NEURON	targets	cell_type	0.65
CANAGLIFLOZIN	protects_against	drug	0.65
NEUROPATHY	modifies	disease	0.65
ALZHEIMER'S	associated_with	disease	0.60
ATHEROSCLEROSIS	regulates	disease	0.60
ATHEROSCLEROSIS	treats	disease	0.60
ACHE	treats	gene	0.60
ALZHEIMER'S	treats	disease	0.60
AKT	contributes_to	gene	0.60
DEMENTIA	impairs	disease	0.60
ALZHEIMER	mediates	disease	0.60
ALZHEIMER'S	mediates	disease	0.60
ALZHEIMER'S DISEASE	mediates	disease	0.60
SIRT1	depleted_in	gene	0.60
MMSE	regulates	biomarker	0.60
ALZHEIMER'S DISEASE	upregulates	disease	0.50
ALZHEIMER	upregulates	disease	0.50
CANCER	regulates	disease	0.50
GFAP	associated_with	gene	0.50
CANCER	involved_in	disease	0.50
ALZHEIMER'S DISEASE	associated_with	disease	0.50
ALZHEIMER	associated_with	disease	0.50
MTOR	regulates	gene	0.50
MACROPHAGES	associated_with	cell_type	0.50
MICROGLIA	regulates	cell_type	0.50
CANCER	activates	disease	0.50
STROKE	associated_with	disease	0.50
CANCER	associated_with	disease	0.50
PARKINSON'S DISEASE	associated_with	disease	0.50
PARKINSON	associated_with	disease	0.50
MACROPHAGE	regulates	cell_type	0.50
MACROPHAGES	inhibits	cell_type	0.50
RAS	inhibits	gene	0.50
DEMENTIA	inhibits	disease	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (1)

Scientific analyses that reference this entity

What are the molecular mechanisms by which GLP-1RAs provide neuroprotective effe

neurodegeneration | 2026-04-14 | 0 hypotheses

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

DIABETES

Understanding Entity Pages

Wiki Pages (21)

GLP-1/GCG Dual Agonist LIGHT-COG (NCT07083154)

cbs-psp-daily-action-plan

Personalized Treatment Plan — Atypical Parkinsonism (CBS/PSP)

Parkinson's Disease

CBS/PSP Supplements Guide

PD Combination Therapy Matrix

nhp-validation-animal-model

Neuroresilience Mechanisms and Evidence

NRF2 Oxidative Stress Pathway

Alzheimer's Disease

PD Cure Roadmap

TREM2 Mechanism Hub

Mitochondrial Quality Control

williams-syndrome

GSK-3β in Neurodegeneration

Autophagy Mechanisms

APOC4 — Apolipoprotein C-IV

Mitophagy Pathway in Neurodegeneration

Melatonin for Tauopathy: Comprehensive Evidence Synthesis

Vascular Cognitive Impairment (VCI)