FGF2

Understanding Entity Pages

This page aggregates everything SciDEX knows about FGF2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

Summary

FGF2 is a gene implicated in neurodegeneration research. Key relationships include: biomarker for, regulates, activates. Associated with ALS, ALZHEIMER'S DISEASE, Aging. Connected to 263 entities in the SciDEX knowledge graph.

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flowchart TD
    FGF2["FGF2<br/>Fibroblast Growth Factor 2"]
    EGR1["EGR1<br/>Early Growth Response 1"]
    ANGPT1["ANGPT1<br/>Angiopoietin 1"]
    PDGFRB["PDGFRB<br/>Platelet Derived Growth<br/>Factor Receptor Beta"]
    VEGFB["VEGFB<br/>Vascular Endothelial<br/>Growth Factor B"]
    TLR4["TLR4<br/>Toll-like Receptor 4"]
    HSPA1A["HSPA1A<br/>Heat Shock Protein<br/>Family A Member 1A"]
    
    Angiogenesis["Angiogenesis<br/>Pathway"]
    Fibroblast_Activation["Fibroblast<br/>Activation"]
    
    ALS["ALS<br/>Amyotrophic Lateral<br/>Sclerosis"]
    Alzheimer["Alzheimer's<br/>Disease"]
    Neurodegeneration["Neurodegeneration"]
    Neuroinflammation["Neuroinflammation"]
    MS["Multiple<br/>Sclerosis"]
    
    EGR1 --|"regulates"|--> FGF2
    FGF2 --|"activates"|--> EGR1
    FGF2 --|"activates"|--> ANGPT1
    FGF2 --|"activates"|--> PDGFRB
    FGF2 --|"activates"|--> VEGFB
    FGF2 --|"regulates"|--> TLR4
    FGF2 --|"regulates"|--> HSPA1A
    
    FGF2 --|"promotes"|--> Angiogenesis
    FGF2 --|"causes"|--> Fibroblast_Activation
    
    FGF2 --|"biomarker_for"|--> ALS
    FGF2 --|"biomarker_for"|--> Alzheimer
    FGF2 --|"biomarker_for"|--> Neurodegeneration
    FGF2 --|"biomarker_for"|--> Neuroinflammation
    FGF2 --|"inhibits"|--> MS
    
    ANGPT1 --> Angiogenesis
    VEGFB --> Angiogenesis
    TLR4 --> Neuroinflammation
    
    style FGF2 fill:#006494
    style EGR1 fill:#4a1a6b
    style ANGPT1 fill:#4a1a6b
    style PDGFRB fill:#4a1a6b
    style VEGFB fill:#4a1a6b
    style TLR4 fill:#4a1a6b
    style HSPA1A fill:#1b5e20
    style Angiogenesis fill:#1b5e20
    style MS fill:#1b5e20
    style ALS fill:#ef5350
    style Alzheimer fill:#ef5350
    style Neurodegeneration fill:#ef5350
    style Neuroinflammation fill:#ef5350
    style Fibroblast_Activation fill:#5d4400