concept

NFKB

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about NFKB: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

685Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

Summary

NFKB is a concept in neurodegeneration research. Key relationships include: associated with, activates, inhibits. Associated with ALS, Als, Alzheimer. Connected to 305 entities in the SciDEX knowledge graph.

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💡 Concept Info

Name	NFKB
Key Genes/Proteins	ABLIM1, IKB, IKK, RANK, C3, IL8
Related Diseases	ALZHEIMER'S DISEASE

Wiki Pages (20)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    NFKB["NFKB"]
    NFKB -->|"regulates"| C3["C3"]
    NFKB -->|"regulates"| IL8["IL8"]
    NFKB -->|"regulates"| GFAP["GFAP"]
    NFKB -->|"regulates"| BACE1["BACE1"]
    NFKB -->|"inhibits"| Als["Als"]
    NFKB -->|"activates"| Cancer["Cancer"]
    BRSK2["BRSK2"] -->|"activates"| NFKB
    STING1["STING1"] -->|"regulates"| NFKB
    ROS["ROS"] -->|"activates"| NFKB
    mitochondrial_ROS["mitochondrial ROS"] -->|"activates"| NFKB
    PINK1["PINK1"] -->|"regulates"| NFKB
    IL_6["IL-6"] -->|"activates"| NFKB
    IL17["IL17"] -->|"activates"| NFKB
    STING["STING"] -->|"activates"| NFKB

Outgoing (374)

Target	Relation	Type	Str
NEUROINFLAMMATION	activates	entity	0.95
SASP	regulates	entity	0.95
SASP	activates	process	0.95
Neuroinflammation	activates	process	0.95
ALZHEIMER'S DISEASE	involved_in	disease	0.95
Immune Development	regulates	process	0.95
Immune Response	regulates	process	0.95
C3	regulates	protein	0.94
NEUROINFLAMMATION	mediates	entity	0.90
IL8	upregulates	protein	0.90
Alzheimer's Disease	contributes_to	disease	0.90
NLRP3	upregulates	protein	0.90
NF-kB signaling	participates_in	pathway	0.90
Neuroinflammation	mediates	process	0.90
IL-6	regulates	protein	0.88
NLRP3	activates	protein	0.85
Inflammation	mediates	process	0.85
BNIP3	downregulates	gene	0.85
Neuroinflammation	involved_in	process	0.85
DNMT1	associated_with	gene	0.80
Intestinal Inflammation	mediates	process	0.80
IL6	upregulates	gene	0.80
TG2	activates	gene	0.80
oxidative stress response	participates_in	pathway	0.80
NFKBIA	triggers_ubiquitination_dependent_degradation_by_TRIM25	protein	0.80
Alzheimer's disease	dysregulated_in	disease	0.80
IFN	interacts_with	pathway	0.80
TLR	interacts_with	pathway	0.80
Alzheimer's disease	implicated_in	disease	0.80
Mtor	associated_with	pathway	0.80
MICROGLIA	inhibits	gene	0.80
ASTROCYTES	inhibits	gene	0.80
UBIQUITIN	activates	gene	0.80
MTOR	associated_with	gene	0.80
Als	inhibits	disease	0.75
Dementia	inhibits	disease	0.75
Alzheimer	associated_with	disease	0.75
MICROGLIA	interacts_with	cell_type	0.75
ASTROCYTES	interacts_with	cell_type	0.75
Capillary Dysfunction	associated_with	phenotype	0.75
IL8	regulates	protein	0.72
GFAP	regulates	protein	0.72
Autophagy	associated_with	pathway	0.70
Autophagy	inhibits	pathway	0.70
BACE1	regulates	protein	0.70
BACE1	activates	protein	0.70
AUTOPHAGY	activates	gene	0.70
AUTOPHAGY	associated_with	gene	0.70
UBIQUITIN	associated_with	gene	0.70
TAU	inhibits	gene	0.70

Incoming (311)

Source	Relation	Type	Str
TGM2	activates	entity	0.95
ABLIM1	activates	protein	0.95
IKB	interacts_with	protein	0.95
IKK	interacts_with	protein	0.95
RANK	activates	protein	0.95
BRSK2	activates	protein	0.90
Polyphenols	associated_with	compound	0.90
IRISIN	inhibits	protein	0.90
IKBA	interacts_with	protein	0.90
NFKBIA	inhibits	protein	0.90
IKBA	inhibits	protein	0.90
IκB	inhibits	protein	0.90
Vitamin B1	inhibits	drug	0.88
Vitamin B2	inhibits	drug	0.88
Vitamin B3	inhibits	drug	0.88
RIPK3	activates	protein	0.87
AKT	activates	protein	0.85
NFE2L2	modulates	gene	0.85
PPARG	modulates	gene	0.85
Microglia	activates	cell_type	0.85
Astrocytes	activates	cell_type	0.85
Copper	activates	compound	0.85
Dopamine	inhibits	compound	0.85
FNDC5	inhibits	protein	0.85
RLN	phosphorylates	protein	0.85
STING1	regulates	gene	0.80
AMPK	interacts_with	protein	0.80
Glutamate	activates	compound	0.80
TAU PROTEIN	interacts_with	protein	0.80
CCN2	regulates	gene	0.80
METHIONINE RESTRICTION	inhibits	biological_process	0.80
Flavonoids	modulates	compound	0.75
APOE	interacts_with	gene	0.75
ROS	activates	process	0.70
mitochondrial ROS	activates	process	0.70
PINK1	regulates	gene	0.70
IL-6	activates	protein	0.70
AUTOPHAGY	inhibits	gene	0.70
IL17	activates	protein	0.68
MACROPHAGE	associated_with	cell_type	0.65
MACROPHAGES	associated_with	cell_type	0.65
APP	phosphorylates	gene	0.65
BACE1	phosphorylates	gene	0.65
STING	activates	protein	0.64
CGAS	activates	protein	0.64
AMYLOID_BETA	activates	protein	0.64
ILK	activates	protein	0.64
AMPK	inhibits	protein	0.64
JUN	participates_in	protein	0.64
ATG5	associated_with	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

NFKB

Understanding Entity Pages

Summary

Wiki Pages (20)

NTF4 Protein

TREM2 Mechanism Hub

Neuroimmune Response in 4R-Tauopathies: Cross-Disease Comparison

Neuroinflammation-Mitochondria Crosstalk Pathway

Genistein for Mild Cognitive Impairment (NCT07385937)

Advanced Glycation End Products in Neurodegeneration

nfkb-neurodegeneration

OTULIN-Tau Regulation Pathway

IL32

Section 182: Microbiome Metabolomics and SCFA Therapy in CBS/PSP

nlrp3-inflammasome

Tolfenamic Acid PSP Trial (NCT04253132)

ERK2 Protein

CYLD Protein — Lysine-Specific Deubiquitinase in Neurodegeneration

SQSTM1 — Sequestosome 1 (p62)

TREM2-SYK Signaling Cascade

c-Rel Protein

ANG Protein