| CBS | Neuronal loss in globus pallidus internus (GPi), substantia nigra pars reticulata (SNr), motor cortex |
| PD | Predominant loss of dopaminergic neurons in substantia nigra pars compacta (SNc) |
| Positive response | ≥30% improvement in UPDRS-III |
| Negative response | <30% improvement |
| Sensitivity for CBS | ~70-80% of CBS patients show no response |
| Specificity | High specificity when marked asymmetry and cortical signs present |
| Differential diagnosis | Helps distinguish from progressive supranuclear palsy (PSP) where some responsiveness may occur |
| Databases | OMIMOrphanetClinicalTrialsPubMed |
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