| Antibody-mediated attack | Autoantibodies target neuronal surface antigens (e.g., VGKC-complex, LGI1, CASPR2, GABA receptors) |
| T-cell mediated cytotoxicity | CD8+ T-cells can directly attack neurons expressing target antigens |
| Paraneoplastic immune response | Tumors express neuronal antigens, triggering cross-reactive antibody production |
| Intrathecal antibody synthesis | B-cells within the CNS produce disease-specific antibodies |
| Amygdala | Central to emotional processing and fear responses |
| Septal nuclei | Cholinergic neurons important for cognition |
| Anterograde amnesia | Inability to form new memories[@sjgren], [@lentiform] |
| Retrograde amnesia | Loss of past memories, often temporally graded |
| Working memory deficits | Difficulty holding information in mind |
| Databases | OMIMOrphanetClinicalTrialsPubMed |
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