| Kinase domain | Phosphorylates target proteins (including itself through autophosphorylation) |
| ROC domain | GTPase activity, regulates protein interactions |
| COR domain | Mediates dimerization |
| LRR domain | Protein-protein interactions |
| WD40 repeat | Scaffold for protein complexes |
| Neuronal signaling | Regulates various signaling pathways in neurons |
| Protein sorting | Controls vesicular trafficking through Rab GTPase interactions |
| Mitochondrial function | Associates with mitochondrial outer membrane |
| Synaptic plasticity | Involved in dopamine receptor signaling |
| G2019S | Common in European and North African populations (up to 30% of familial PD in some populations) |
| R1441G | Highly prevalent in Basque population (up to 50% of familial PD) |
| G2385R | Risk factor in East Asian populations |
| Databases | OMIMOrphanetClinicalTrialsPubMed |
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