mechanism 3,582 words KG: lysosomal dysfunction 2026-04-01
kind:mechanismsection:mechanismsstate:published
Contents

Lysosomal Dysfunction in Neurodegeneration

Mechanism Info
NameLysosomal Dysfunction in Neurodegeneration
SummaryLysosomal dysfunction as a central mechanism in neurodegenerative diseases including Parkinson's, Alzheimer's, FTD, ALS, and lysosomal storage disorders
Key Genes/ProteinsTREM2 p.Q33X mutation, TBK1
Related Diseasesmitochondrial dysfunction, carcinoma, Alzheimer's disease, ALS, FTD
Related PathwaysTFEB activation
Linked Hypotheses1 hypotheses

Knowledge Graph