disease

FTD

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about FTD: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

903Connections

2Hypotheses

7Analyses

50Outgoing

50Incoming

No summary available yet. View on Wiki →

Disease Info

Behavioral variant FTD (bvFTD)	Progressive changes in personality, social conduct, and executive function, with early behavioral disinhibition, apathy, loss of empathy, and compulsive/ritualistic behaviors
Associated Genes	TAU, TDP43, C9ORF72, hexanucleotide repeat expansions, C9orf72, TDP-43, CAT, APOE
KG Connections	518 knowledge graph edges
Databases	OMIM Orphanet ClinicalTrials PubMed

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

AAV Gene Therapy for Neurodevelopmental Epilepsy — Competitive Landscape & Delivery Alternatives

therapeutic · 15567 words

→

Clinical Management Guide for CBS/PSP

therapeutic · 15224 words

→

Progressive Supranuclear Palsy (PSP)

disease · 12907 words

→

Pathway Diagram

graph TD
    FTD["FTD"] -->|"interacts"| FUS["FUS"]
    FTD["FTD"] -->|"interacts"| LC3["LC3"]
    FTD["FTD"] -->|"interacts"| OPTN["OPTN"]
    FTD["FTD"] -->|"interacts"| P62["P62"]
    FTD["FTD"] -->|"interacts"| SQSTM1["SQSTM1"]
    FTD["FTD"] -->|"interacts"| STING["STING"]
    ALS["ALS"] -->|"activates"| FTD["FTD"]
    NEURODEGENERATION["NEURODEGENERATION"] -->|"associated"| FTD["FTD"]
    C9ORF72["C9ORF72"] -->|"causes"| FTD["FTD"]
    AUTOPHAGY["AUTOPHAGY"] -->|"activates"| FTD["FTD"]
    style FTD fill:#ef5350,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (284)

Target	Relation	Type	Str
UBQLN2	associated_with	gene	0.80
NEURON	increases	cell_type	0.65
NEURODEGENERATION	expressed_in	disease	0.65
MOTOR NEURON	activates	cell_type	0.65
NEURON	activates	cell_type	0.65
NEURONS	activates	cell_type	0.65
STING	causes	gene	0.65
TREM2	contributes_to	gene	0.65
MICROGLIA	contributes_to	cell_type	0.65
NEURON	contributes_to	cell_type	0.65
P53	causes	gene	0.65
MICROGLIA	regulates	cell_type	0.65
ROS	activates	gene	0.65
TAU	promotes	gene	0.65
RAPAMYCIN	interacts_with	drug	0.65
TAU	interacts_with	gene	0.65
OPTN	transports	gene	0.65
SQSTM1	transports	gene	0.65
TREM2	associated_with	gene	0.65
TAU	causes	gene	0.65
NEURON	phosphorylates	cell_type	0.65
NEURONS	phosphorylates	cell_type	0.65
TAU	phosphorylates	gene	0.65
PARKIN	impairs	gene	0.65
PARKINSON	impairs	disease	0.65
PARKINSON'S DISEASE	impairs	disease	0.65
NEURON	regulates	cell_type	0.65
NEURON	expressed_in	cell_type	0.65
NEURONS	expressed_in	cell_type	0.65
NEURON	inhibits	cell_type	0.65
NOTCH	associated_with	gene	0.65
FUS	interacts_with	gene	0.60
LC3	interacts_with	gene	0.60
OPTN	interacts_with	gene	0.60
P62	interacts_with	gene	0.60
SQSTM1	interacts_with	gene	0.60
STING	interacts_with	gene	0.60
UBIQUITIN	interacts_with	gene	0.60
ULK1	interacts_with	gene	0.60
HIF1A	causes	gene	0.60
JNK	activates	gene	0.60
MAPK	activates	gene	0.60
NLRP3	activates	gene	0.60
OPTN	activates	gene	0.60
P62	activates	gene	0.60
PARKIN	activates	gene	0.60
PARKINSON	activates	disease	0.60
PINK1	activates	gene	0.60
RB1	activates	gene	0.60
RIPK3	activates	gene	0.60

Incoming (619)

Source	Relation	Type	Str
ALS	associated_with	disease	1.00
ALS	interacts_with	disease	1.00
ALS	activates	disease	1.00
ALZHEIMER'S DISEASE	associated_with	disease	1.00
PARKINSON'S DISEASE	associated_with	disease	1.00
TARDBP	associated_with	gene	1.00
TAU	associated_with	protein	0.98
ALS	causes	disease	0.98
ALS	regulates	disease	0.98
TARDBP	causes	protein	0.95
TARDBP	involved_in	protein	0.95
FUS	involved_in	protein	0.95
VCP	associated_with	gene	0.95
Tau 3R/4R Ratio	biomarker_for	biomarker	0.93
STING	associated_with	protein	0.90
GGGGCC Repeat Expansion	associated_with	biomarker	0.90
Rbp Dysfunction	contributes_to	mechanism	0.90
TDP-43	implicated_in	protein	0.90
TDP-43	causes	protein	0.90
Ggggcc Repeat Expansion	risk_factor_for	biomarker	0.90
Cryptic Hdgfl2	biomarker_for	biomarker	0.90
C9ORF72	causes	gene	0.87
G3BP1	implicated_in	entity	0.85
FUS	associated_with	gene	0.82
MAPT	associated_with	gene	0.82
vesicle trafficking	associated_with	pathway	0.80
C9ORF72	implicated_in	gene	0.80
C9ORF72 REPEAT RNA	causes	compound	0.80
DIPEPTIDE REPEAT PROTEINS (DPRS)	causes	compound	0.80
stress_granule_formation	contributes_to	pathway	0.80
SOD1	associated_with	gene	0.74
AMYLOID	associated_with	protein	0.74
TDP43	associated_with	protein	0.72
VESICLE_TRAFFICKING	associated_with	pathway	0.72
GGGGCC_repeat	causes	genetic_variant	0.72
LC3	activates	protein	0.72
hexanucleotide repeat expansions	causes	gene	0.70
C9orf72	causes	gene	0.70
lysosomal dysfunction	associated_with	process	0.70
C9orf72	associated_with	gene	0.70
TDP-43	associated_with	protein	0.70
APOE	associated_with	gene	0.66
ALZHEIMER'S DISEASE	activates	disease	0.66
TNF	associated_with	gene	0.66
FRONTAL	causes	brain_region	0.65
ALS	expressed_in	disease	0.65
ALS	biomarker_for	disease	0.65
AMYOTROPHIC LATERAL SCLEROSIS	accumulates_in	disease	0.65
DEMENTIA	accumulates_in	disease	0.65
FRONTOTEMPORAL	accumulates_in	disease	0.65

Targeting Hypotheses (2)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Stathmin-2 Splice Switching to Prevent Axonal Degeneration A	0.664	neurodegeneration	RNA binding protein dysregulation across
Microglial AIM2 Inflammasome as the Primary Driver of TDP-43	0.601	neurodegeneration	What are the mechanisms by which gut mic

Mentioning Analyses (7)

Scientific analyses that reference this entity

How does FUS loss-of-function in TAZ regulation contribute to ALS/FTD pathogenes

neurodegeneration | 2026-04-14 | 1 hypotheses Top: 0.606

RNA binding protein dysregulation across ALS FTD AD

neurodegeneration | 2026-04-13 | 2 hypotheses Top: 0.664

How do pathological stress granules in neurodegeneration escape TRIM21/autophagy

neurodegeneration | 2026-04-06 | 0 hypotheses

RNA binding protein dysregulation across ALS FTD and AD

neurodegeneration | 2026-04-01 | 7 hypotheses Top: 0.490

TDP-43 phase separation therapeutics for ALS-FTD

neurodegeneration | 2026-04-01 | 7 hypotheses Top: 0.575

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

FTD

Understanding Entity Pages

Wiki Pages (21)

Frontotemporal Dementia (FTD)

cbs-psp-daily-action-plan

Personalized Treatment Plan — Atypical Parkinsonism (CBS/PSP)

AAV Gene Therapy for Neurodevelopmental Epilepsy — Competitive Landscape & Delivery Alternatives

Clinical Management Guide for CBS/PSP

Progressive Supranuclear Palsy (PSP)

Corticobasal Syndrome (CBS)

Novel Therapy Index

Parkinson's Disease

primary-progressive-aphasia

calcium-dysregulation-comparison

Corticobasal Degeneration (CBD)

nimodipine-als

Therapeutics

NPM1 Gene

Section 162: Advanced Antioxidant and Redox Therapy in CBS/PSP

Frontotemporal Dementia (FTD) Mechanistic Pathway

neuroinflammation

Microglial Cells — Cell Type Hierarchy

TREM2 Mechanism Hub

Mitochondrial Quality Control

Pathway Diagram

Outgoing (284)

Incoming (619)

Targeting Hypotheses (2)

Mentioning Analyses (7)

How does FUS loss-of-function in TAZ regulation contribute to ALS/FTD pathogenes

RNA binding protein dysregulation across ALS FTD AD

How do pathological stress granules in neurodegeneration escape TRIM21/autophagy

RNA binding protein dysregulation across ALS FTD and AD

TDP-43 phase separation therapeutics for ALS-FTD

TDP-43 phase separation therapeutics for ALS-FTD

RNA binding protein dysregulation across ALS FTD and AD

Related Papers (0)