Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about Carcinoma: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
Carcinoma is a disease characterized by neurodegeneration research. Key relationships include: activates, therapeutic target, associated with. Associated with Aging, Als, Alzheimer. Connected to 1861 entities in the SciDEX knowledge graph.
| Associated Genes | TCF4, MYC, LC3, MTOR, BECN1, CTNNB1, AXIN2, GAPDH |
| KG Connections | 2168 knowledge graph edges |
| Databases | OMIMOrphanetClinicalTrialsPubMed |
Knowledge base pages for this entity
graph TD
Carcinoma["Carcinoma"] -->|"expressed in"| Dna_Methylation["Dna Methylation"]
Carcinoma["Carcinoma"] -->|"therapeutic target"| Wnt["Wnt"]
Carcinoma["Carcinoma"] -->|"activates"| Glycolysis["Glycolysis"]
Carcinoma["Carcinoma"] -->|"interacts"| Akt["Akt"]
Carcinoma["Carcinoma"] -.->|"inhibits"| Apoptosis["Apoptosis"]
Carcinoma["Carcinoma"] -->|"therapeutic target"| Apoptosis_1["Apoptosis"]
IDH1["IDH1"] -->|"therapeutic target"| Carcinoma["Carcinoma"]
VEGFA["VEGFA"] -->|"therapeutic target"| Carcinoma["Carcinoma"]
MDM4["MDM4"] -->|"therapeutic target"| Carcinoma["Carcinoma"]
APOB["APOB"] -->|"therapeutic target"| Carcinoma["Carcinoma"]
style Carcinoma fill:#ef5350,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| Glycolysis | activates | pathway | 1.00 |
| Apoptosis | inhibits | pathway | 1.00 |
| Apoptosis | therapeutic_target | pathway | 1.00 |
| Ferroptosis | activates | pathway | 1.00 |
| Mtor | activates | pathway | 1.00 |
| Mapk | activates | pathway | 1.00 |
| Hepatitis | associated_with | disease | 1.00 |
| Autophagy | activates | pathway | 1.00 |
| Inflammation | associated_with | disease | 1.00 |
| Autophagy | therapeutic_target | pathway | 1.00 |
| Mtor | therapeutic_target | pathway | 1.00 |
| Apoptosis | activates | pathway | 1.00 |
| Drug Resistance | therapeutic_target | pathway | 1.00 |
| Metastasis | activates | pathway | 1.00 |
| Metastasis | therapeutic_target | pathway | 1.00 |
| Invasion | therapeutic_target | pathway | 1.00 |
| Tumor Microenvironment | therapeutic_target | pathway | 1.00 |
| Inflammation | therapeutic_target | disease | 1.00 |
| Pi3K/Akt | activates | pathway | 1.00 |
| Inflammation | activates | disease | 1.00 |
| Hepatocellular Carcinoma | associated_with | disease | 1.00 |
| Metastasis | associated_with | pathway | 1.00 |
| Hepatocellular Carcinoma | activates | disease | 1.00 |
| Invasion | activates | pathway | 1.00 |
| Hepatocellular Carcinoma | therapeutic_target | disease | 1.00 |
| Tumor Microenvironment | activates | pathway | 1.00 |
| Wnt | therapeutic_target | pathway | 1.00 |
| Autophagy | associated_with | pathway | 1.00 |
| Wnt | activates | pathway | 1.00 |
| Nf-Κb | activates | pathway | 1.00 |
| Pi3K/Akt | therapeutic_target | pathway | 1.00 |
| Mapk | therapeutic_target | pathway | 1.00 |
| Immune Checkpoint | inhibits | pathway | 1.00 |
| Lung Cancer | therapeutic_target | disease | 0.95 |
| Lung Cancer | associated_with | disease | 0.95 |
| Glycolysis | therapeutic_target | pathway | 0.90 |
| Oxidative Stress | therapeutic_target | pathway | 0.90 |
| Immune Response | activates | pathway | 0.90 |
| Oxidative Stress | activates | pathway | 0.90 |
| Tgf-Β | activates | pathway | 0.90 |
| Autophagy | regulates | pathway | 0.90 |
| Mapk | inhibits | pathway | 0.90 |
| Lipid Metabolism | therapeutic_target | pathway | 0.90 |
| Glycolysis | regulates | pathway | 0.90 |
| Invasion | treats | pathway | 0.90 |
| Mtor | treats | pathway | 0.90 |
| Nf-Κb | therapeutic_target | pathway | 0.90 |
| Autophagy | implicated_in | pathway | 0.90 |
| Epithelial-Mesenchymal Transition | activates | pathway | 0.90 |
| Invasion | expressed_in | pathway | 0.90 |
| Source | Relation | Type | Str |
|---|---|---|---|
| STAT3 | activates | gene | 1.00 |
| EGFR | activates | gene | 1.00 |
| GENES | therapeutic_target | gene | 1.00 |
| P62 | activates | gene | 1.00 |
| GENES | expressed_in | gene | 1.00 |
| DNA | associated_with | gene | 1.00 |
| Cancer | associated_with | disease | 1.00 |
| Als | associated_with | disease | 1.00 |
| GENES | activates | gene | 1.00 |
| PI3K | activates | gene | 1.00 |
| AKT | activates | gene | 1.00 |
| TP53 | associated_with | gene | 1.00 |
| NRF2 | activates | gene | 1.00 |
| PI3K | therapeutic_target | gene | 1.00 |
| MTOR | therapeutic_target | gene | 1.00 |
| AKT | therapeutic_target | gene | 1.00 |
| DNA | activates | gene | 1.00 |
| STING | activates | gene | 1.00 |
| EGFR | therapeutic_target | gene | 1.00 |
| MYC | activates | gene | 1.00 |
| DNA | therapeutic_target | gene | 1.00 |
| ERK | activates | gene | 1.00 |
| KRAS | activates | gene | 1.00 |
| GENES | associated_with | entity | 1.00 |
| INFLAMMATION | therapeutic_target | gene | 1.00 |
| AUTOPHAGY | therapeutic_target | gene | 1.00 |
| CANCER | activates | gene | 1.00 |
| CANCER | therapeutic_target | gene | 1.00 |
| APOPTOSIS | therapeutic_target | gene | 1.00 |
| CANCER | associated_with | gene | 1.00 |
| CANCER | expressed_in | gene | 1.00 |
| APOPTOSIS | activates | gene | 1.00 |
| FERROPTOSIS | activates | gene | 1.00 |
| CANCER | regulates | gene | 1.00 |
| AUTOPHAGY | associated_with | gene | 1.00 |
| CANCER | inhibits | gene | 1.00 |
| APOPTOSIS | inhibits | gene | 1.00 |
| PTEN | activates | gene | 1.00 |
| AUTOPHAGY | activates | gene | 1.00 |
| INFLAMMATION | activates | gene | 1.00 |
| P53 | activates | gene | 1.00 |
| CYTOKINES | activates | gene | 1.00 |
| UBIQUITIN | activates | gene | 1.00 |
| NF-ΚB | activates | gene | 1.00 |
| INFLAMMATION | associated_with | gene | 1.00 |
| BCL-2 | therapeutic_target | gene | 1.00 |
| CANCER | causes | gene | 1.00 |
| RAS | activates | gene | 1.00 |
| ROS | activates | gene | 1.00 |
| CANCER | implicated_in | gene | 1.00 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||