gene

TBK1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about TBK1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

1327Connections

1Hypotheses

2Analyses

50Outgoing

50Incoming

Summary

TBK1 is a gene implicated in neurodegeneration research. Key relationships include: activates, associated with, regulates. Associated with ALS, Aging, Als. Connected to 636 entities in the SciDEX knowledge graph.

View on Wiki →

🧬 Gene Info

Gene Symbol	TBK1
Full Name	TANK Binding Kinase 1
Chromosome	12q14.2
Protein Type	Serine/Threonine Kinase
Function	TBK1 belongs to the IκB kinase (IKK) subfamily of kinases, originally characterized for its role in activating innate immune signaling through the induction of type I interferons in response to viral
Primary Expression	Motor cortex, Spinal cord, Immune cells
Molecular Weight	84 kDa
Pathways	Apoptosis, Autophagy, Epigenetic, Er Stress, Immune Response
UniProt ID	Q9UHD2
NCBI Gene ID	29110
Ensembl ID	ENSG00000183735
OMIM	604834
GeneCards	TBK1
Human Protein Atlas	TBK1
Associated Diseases	ALS, AUTOPHAGY, AXONAL DEGENERATION, Aging, Alzheimer
Known Drugs/Compounds	amlexanox, rapamycin
Interactions	CHMP2B, OVERVIEW, VALOSIN, MTOR, NDP52, FIP200
SciDEX Hypotheses	TBK1 Loss-of-Function Amplifies C1q-Mediated Synap
KG Connections	1327 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: TBK1 — AlphaFold Q9UHD2 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    TBK1["TBK1"] -->|"Phosphorylates"| SQSTM1["SQSTM1"]
    TBK1["TBK1"] -->|"Activates"| autophagy["autophagy"]
    TBK1["TBK1"] -->|"Phosphorylates"| p62["p62"]
    TBK1["TBK1"] -->|"Increases Risk"| p62_aggregates["p62 aggregates"]
    TBK1["TBK1"] -->|"Activates"| ULK1["ULK1"]
    TBK1["TBK1"] -->|"Phosphorylates"| P62_SQSTM1["P62_SQSTM1"]
    TBK1["TBK1"] -->|"Promotes"| mitophagy["mitophagy"]
    TBK1["TBK1"] -->|"Regulates"| OPTN["OPTN"]
    FIP200["FIP200"] -->|"Inhibits"| TBK1["TBK1"]
    amlexanox["amlexanox"] -->|"Inhibits"| TBK1["TBK1"]
    proteotoxic_stress["proteotoxic stress"] -->|"Activates"| TBK1["TBK1"]
    CGAS_STING["CGAS_STING"] -->|"Activates"| TBK1["TBK1"]
    STING1["STING1"] -->|"Activates"| TBK1["TBK1"]
    style TBK1 fill:#8d4900,color:#e0e0e0
    style SQSTM1 fill:#0d47a1,color:#e0e0e0
    style autophagy fill:#9C27B0,color:#e0e0e0
    style p62 fill:#0d47a1,color:#e0e0e0
    style p62_aggregates fill:#607D8B,color:#e0e0e0
    style ULK1 fill:#0d47a1,color:#e0e0e0
    style P62_SQSTM1 fill:#0d47a1,color:#e0e0e0
    style mitophagy fill:#1b5e20,color:#e0e0e0
    style OPTN fill:#0d47a1,color:#e0e0e0
    style FIP200 fill:#0d47a1,color:#e0e0e0
    style amlexanox fill:#00838f,color:#e0e0e0
    style proteotoxic_stress fill:#607D8B,color:#e0e0e0
    style CGAS_STING fill:#9C27B0,color:#e0e0e0
    style STING1 fill:#0d47a1,color:#e0e0e0

Outgoing (688)

Target	Relation	Type	Str
IRF3	activates	gene	1.00
STING	activates	gene	1.00
CGAS	activates	gene	1.00
Als	activates	disease	1.00
Immune Response	activates	pathway	1.00
Als	associated_with	disease	1.00
CGAS-STING	activates	gene	1.00
DNA	activates	gene	1.00
Innate Immunity	activates	pathway	1.00
Als	interacts_with	disease	0.95
Infection	activates	disease	0.95
Frontotemporal Dementia	associated_with	disease	0.95
amyotrophic lateral sclerosis	risk_factor_for	disease	0.95
frontotemporal dementia	risk_factor_for	disease	0.95
Amyotrophic Lateral Sclerosis	risk_factor_for	disease	0.95
Frontotemporal Dementia	risk_factor_for	disease	0.95
SQSTM1	phosphorylates	protein	0.90
autophagy	activates	pathway	0.90
p62	phosphorylates	protein	0.90
CLASS III PHOSPHATIDYLINOSITOL 3-KINASE COMPLEX I	binds	protein	0.90
OPTN	binds	protein	0.90
macroautophagy	regulates	process	0.90
Autophagolysosomal Dysfunction	contributes_to	phenotype	0.90
Optineurin	binds	protein	0.90
Autophagolysosomal dysfunction	causes	process	0.90
Motoneuron pathology	causes	pathology	0.90
neuroinflammation	does_not_cause	process	0.90
amyotrophic lateral sclerosis	implicated_in	disease	0.90
Autophagy	activates	pathway	0.90
Autophagy	regulates	pathway	0.90
Autophagy	interacts_with	pathway	0.90
tau phosphorylation	upstream_of	process	0.88
Amyotrophic Lateral Sclerosis	implicated_in	disease	0.88
NDP52	modulates	protein	0.85
OPTN	phosphorylates	protein	0.85
lysosomal dysfunction	prevents	phenotype	0.85
neurite outgrowth	promotes	phenotype	0.85
STING	associated_with	protein	0.85
ULK1	phosphorylates	protein	0.85
Selective Autophagy	regulates	process	0.85
Optineurin	phosphorylates	protein	0.85
Autophagolysosomal Dysfunction	regulates	phenotype	0.85
Tumor	activates	disease	0.85
Amyotrophic Lateral Sclerosis	associated_with	disease	0.85
Dementia	associated_with	disease	0.85
Als	regulates	disease	0.85
Als	inhibits	disease	0.85
Inflammation	inhibits	disease	0.85
Tau Phosphorylation	mediates	process	0.85
ULK1	activates	protein	0.82

Incoming (639)

Source	Relation	Type	Str
STING	activates	gene	1.00
UBIQUITIN	activates	gene	1.00
AUTOPHAGY	interacts_with	gene	1.00
FIP200	inhibits	protein	0.90
amlexanox	inhibits	drug	0.90
ZBP1	interacts_with	protein	0.90
CGAS	activates	gene	0.90
P62	activates	gene	0.90
P62	regulates	gene	0.90
SNCA	activates	protein	0.85
NAP1	binds_to	protein	0.85
STING	associated_with	protein	0.85
proteotoxic stress	activates	phenotype	0.80
STING	binds	protein	0.80
MARCH1	ubiquitinates	gene	0.80
BTK	activates	gene	0.80
LC3	activates	gene	0.80
SQSTM1	activates	gene	0.80
FIP200	interacts_with	gene	0.80
IRF3	activates	gene	0.80
OPTN	interacts_with	gene	0.80
STING	regulates	gene	0.80
UBIQUITIN	interacts_with	gene	0.80
GENES	activates	gene	0.80
AUTOPHAGY	inhibits	gene	0.80
CYTOKINES	activates	gene	0.80
AUTOPHAGY	activates	gene	0.80
AUTOPHAGY	regulates	gene	0.80
ALS	associated_with	gene	0.80
CGAS_STING	activates	pathway	0.72
SQSTM1	associated_with	gene	0.70
OPTN	associated_with	gene	0.70
PARKIN	associated_with	gene	0.70
PINK1	interacts_with	gene	0.70
PARKIN	interacts_with	gene	0.70
STING1	activates	protein	0.70
STING	inhibits	gene	0.70
OPTN	activates	gene	0.70
TAX1BP1	regulates	gene	0.70
NBR1	regulates	gene	0.70
TAX1BP1	interacts_with	gene	0.70
P62	interacts_with	gene	0.70
MAVS	activates	gene	0.70
IRF3	inhibits	gene	0.70
TLR3	activates	gene	0.70
TLR4	activates	gene	0.70
NDP52	regulates	gene	0.70
CGAS	regulates	gene	0.70
STING	interacts_with	gene	0.70
AUTOPHAGY	associated_with	gene	0.70

Targeting Hypotheses (1)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
TBK1 Loss-of-Function Amplifies C1q-Mediated Synapse Elimina	0.520	neurodegeneration	How do the seven novel ALS genes functio

Mentioning Analyses (2)

Scientific analyses that reference this entity

How do the seven novel ALS genes function in animal models to cause neurodegener

neurodegeneration | 2026-04-13 | 1 hypotheses Top: 0.520

Senolytic therapy for age-related neurodegeneration

neurodegeneration | 2026-04-01 | 8 hypotheses Top: 0.703

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

TBK1

Understanding Entity Pages

Summary

Wiki Pages (21)

TBK1 — TANK Binding Kinase 1

Novel Therapy Index

Frontotemporal Dementia (FTD) Mechanistic Pathway

neuroinflammation

Autophagy Mechanisms

Mitophagy Pathway in Neurodegeneration

Gene-Mechanism-Therapy Causal Chains

Motor Neuron Disease (MND)

Autophagy-Lysosomal Impairment Comparison — AD/PD/ALS/FTD/HD

Neuroinflammation Across AD, PD, ALS, FTD, and HD

ZFYVE26 Gene

Lysosomal Dysfunction in Neurodegeneration

Mitophagy Pathway in Neurodegeneration

TDP-43 Proteinopathy in Amyotrophic Lateral Sclerosis

CBS/PSP Genetic Architecture

Autophagy Failure Comparison -- AD/PD/ALS/FTD/HD

cGAS-STING Signaling in Parkinson's Disease

TREM2 in Frontotemporal Dementia

pink1-parkin-mitophagy-pd-causal-chain

ALS Pipeline

ftd-tdp43-pathway