| Gene Symbol | MAP2K3 |
| Full Name | Mitogen-Activated Protein Kinase Kinase 3 |
| Aliases | Page for MAP2K3 |
| Chromosome | 6p21.3 |
| Protein Type | Kinase |
| Function | is a dual-specificity protein kinase that serves as a critical upstream activator of the p38 MAPK signaling pathway. |
| Primary Expression | both neurons and glial cells, where its activation contributes to neuroinflammation, tau pathology, and synaptic |
| Molecular Weight | 38 kDa |
| Amino Acids | 347 aa |
| Exons | 10 |
| Pathways | MAPK signaling, MAPK, NF-κB |
| UniProt ID | [P46734](https://www.uniprot.org/uniprot/P46734) |
| Ensembl ID | ENSG00000099695 |
| GeneCards | MAP2K3 |
| Human Protein Atlas | MAP2K3 |
| Associated Diseases | neurodegeneration |
| KG Connections | 2 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |
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