| Gene Symbol | ent-gene-d289a3d6 |
| Category | Disease-Modifying Therapy |
| Target | NRF2 (NFE2L2) / KEAP1 pathway |
| Development Stage | Phase I-II |
| Mechanism | Antioxidant response, anti-inflammatory, cytoprotection |
| KEAP1 binding | Cytoplasmic sequestration and degradation |
| p62 phosphorylation | Competes with NRF2 for KEAP1 binding |
| Acetylation | Modulates nuclear import and DNA binding |
| Phosphorylation | Multiple kinases regulate NRF2 activity |
| Epigenetic regulation | Promoter methylation reduces NRF2 expression |
| KG Connections | 2 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |