| History of Stroke | Previous ischemic events significantly increase dementia risk |
| Hypertension | The most important modifiable risk factor |
| Diabetes Mellitus | Contributes to small vessel disease |
| Atrial Fibrillation | Cardioembolic strokes are a common cause |
| Hypercholesterolemia | Atherosclerosis promotes large vessel disease |
| Smoking | Tobacco use accelerates cerebrovascular damage |
| Angular Gyrus | Critical for language and spatial processing |
| Thalamus | Gateway for cognitive and memory pathways |
| Basal Ganglia | Executive function and motor planning |
| Frontal White Matter | Executive function and behavioral regulation |
| Internal Capsule | Motor and cognitive pathways[^6] |
| Size | Larger infarcts cause more extensive damage |
| Databases | OMIMOrphanetClinicalTrialsPubMed |
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